Publications

 

 

Original Articles

1. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P, Pan R, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Zuniga S, Sola I, Enjuanes L, Meyerholz DK, Fortney K, McCray PB Jr, Perlman S. (2022) Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19. Nature. 605(7908):146-151. doi: 10.1038/s41586-022-04630-3. Epub 2022 Mar 21. PMID: 35314834; PMCID: PMC9783543.
2. Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S. PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment. Cell Rep. 7;39(10):110914. doi: 10.1016/j.celrep.2022.110914. PMID: 35675777.
3. Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM.(2022) LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 12;119(15): e2118816119. doi: 10.1073/pnas.2118816119. Epub 2022 Apr 8. PMID: 35394866; PMCID: PMC9169816.
4. Siriwach R, Ngo AQ, Higuchi M, Arima K, Sakamoto S, Watanabe A, Narumiya S, Thumkeo D. (2022) Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience. 21;25(4):104130. doi: 10.1016/j.isci.2022.104130. PMID: 35391830; PMCID: PMC8980802.
5. Kawamura N, Katsuura G, Yamada-Goto N, Nakama R, Kambe Y, Miyata A, Furuyashiki T, Narumiya S, Ogawa Y, Inui A. (2022) Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice. Sci Rep. 2022 Jul 23;12(1):12604. doi:10.1038/s41598-022-16944-3. PMID: 35871167; PMCID: PMC9308795.
6. Amano H, Eshima K, Ito Y, Nakamura M, Kitasato H, Ogawa F, Hosono K, Iwabuchi K, Uematsu S, Akira S, Narumiya S, Majima M. (2022) The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells. Cardiovasc Res. 20:cvac137. doi: 10.1093/cvr/cvac137. Epub ahead of print. PMID: 35986688.
7. Robb CT, Zhou Y, Felton JM, Zhang B, Goepp M, Jheeta P, Smyth DJ, Duffin R, Vermeren S, Breyer RM, Narumiya S, McSorley HJ, Maizels RM, Schwarze JKJ, Rossi AG, Yao C. (2023) Metabolic regulation by prostaglandin E2, impairs lung group 2 innate lymphoid cell responses. Allergy. 78(3):714-730. doi: 10.1111/all.15541. Epub 2022 Oct 14. PMID: 36181709.
8. Ratklao Siriwach, Anh Quynh Ngo, Makio Higuchi, Kentaro Arima, Satoko Sakamoto, Akira Watanabe, Shuh Narumiya, and Dean Thumkeo, Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience, Volume 25, Issue 4, 2022, 104130, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2022.104130.
9. Kremer K.N., Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R and Torres R.M. (2022) LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc. Natl. Acad. Sci. U.S.A. 2022 Apr 12;119(15):e2118816119. doi: 10.1073/pnas.2118816119.
10. Yamane S, Amano H, Ito Y, Betto T, Matsui Y, Koizumi W, Narumiya S, Majima M. The role of thromboxane prostanoid receptor signaling in gastric ulcer healing. Int J Exp Pathol. 2022 Feb;103(1):4-12. doi: 10.1111/iep.12410. Epub 2021 Oct 16. PMID: 34655121
11. Goepp M, Crittenden S, Zhou Y, Rossi AG, Narumiya S, Yao C. Prostaglandin E₂ directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling. Immunology. 2021 Dec;164(4):777-791. doi: 10.1111/imm.13417. Epub 2021 Oct 1. PMID: 34529833
12. Nigoro K, Ito H, Kawata T, Ishie S, Morita Y, Nishitani K, Aoyama T, Tabara Y, Matsuda F, Narumiya S, Matsuda S. Differential Contribution of the Medial and the Lateral Side of the Joint to Symptoms in Knee Osteoarthritis: A Radiographic and Laboratory Analysis in the Nagahama Study. CARTILAGE. December 2021:1648S-1657S. doi:10.1177/19476035211025817
13. Roy Wong LY, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Pezzulo AA, Szachowicz PJ, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Meyerholz DK, Fortney K, McCray PB, Perlman S. Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19. bioRxiv. 2021 Apr 21:2021.04.20.440676. doi: 10.1101/2021.04.20.440676. Preprint.
14. Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A, O’Connor RA, Davies L, Li XF, Yao HX, Ho GT, Zheng X, Mair A, Vermeren S, Qian BZ, Mole DJ, Gerasimidis K, Schwarze JKJ, Breyer RM, Arends MJ, O’Donnell VB, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Rossi AG, Howie SE, Yao C. Prostaglandin E₂ promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances, 2021 Feb 12;7(7):eabd7954. doi: 10.1126/sciadv.abd7954. Print 2021 Feb.
15. Matsuda H, Ito Y, Hosono K, Tsuru S, Inoue T, Nakamoto S, Kurashige C, Hirashma M, Narumiya S, Okamoto H, Majima M. Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm. Arterioscler Thromb Vasc Biol. 2021 Feb 11:ATVBAHA120315507. doi: 10.1161/ATVBAHA.120.315507.
16. Nigoro K, Ito H, Kawata T, Nishitani K, Tabara Y, Matsuda F, Narumiya S, Matsuda S; Nagahama Study group. (2020) Obesity with radiological changes or depression was associated with worse knee outcom e in general population: a cluster analysis in the Nagahama study. Arthritis Res Ther. 22(1):280. doi: 10.1186/s13075-020-02375-w.
17. Kawaguchi C, Shintani N, Hayata-Takano A, Hatanaka M, Kuromi A, Nakamura R, Yamano Y, Shintani Y, Nagai K, Tsuchiya S, Sugimoto Y, Ichikawa A, Okuno Y, Urade Y, Hirai H, Nagata KY, Nakamura M, Narumiya S, Nakazawa T, Kasai A, Ago Y, Takuma K, Baba A, Hashimoto H. (2020) Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the c entral circadian rhythm in mice. Commun Biol. 3(1):557. doi: 10.1038/s42003-020-01281-w.
18. Abe I, Terabayashi T, Hanada K, Kondo H, Teshima Y, Ishii Y, Miyoshi M, Kira S, Saito S, Tsuchimochi H, Shirai M, Yufu K, Arakane M, Daa T, Thumkeo D, Narumiya S, Takahashi N, Ishizaki T. (2020) Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction. Cardiovasc Res. 2020 Jul 9:cvaa206. doi: 10.1093/cvr/cvaa206.
19. Zheng J, Sariol A, Meyerholz D, Zhang Q, Abrahante Lloréns JE, Narumiya S, Perlman S. J. (2020) Prostaglandin D₂ signaling in dendritic cells is critical for the development of EAE. Autoimmun. 2020 Jul 2:102508. doi: 10.1016/j.jaut.2020.102508.
20. Emori T, Kasahara M, Sugahara S, Hashimoto M, Ito H, Narumiya S, Higashi Y, Fujii Y. (2020) Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib. Eur J Pharmacol. 2020 Sep 5;882:173238. doi: 10.1016/j.ejphar.2020.173238.
21. Hosono K, Kojo K, Narumiya S, Majima M, Ito Y. (2020) Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis. Biomed Pharmacother. 2020 Aug;128:110264. doi: 10.1016/j.biopha.2020.110264.
22. Nakamoto S, Ito Y, Nishizawa N, Goto T, Kojo K, Kumamoto Y, Watanabe M, Narumiya S, Majima M. (2020) EP3 signaling in dendritic cells promotes liver repair by inducing IL-13-mediated macrophage differentiation in mice. FASEB J. 34, 5610-5627. doi: 10.1096/fj.201901955R.
23. Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel MF, Narumiya S. (2020) mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. Science Advances, 6(1), eaay2432
24. Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T. (2019) Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E₂ synthesis in the brain and their behavioral relevance Sci Rep, 9(1), 17548.
25. Akamatsu M, Mikami N, Ohkura N, Kawakami R, Kitagawa Y, Sugimoto A, Hirota K, Nakamura N, Ujihara S, Kurosaki T, Hamaguchi H, Harada H, Xia G, Morita Y, Aramori I, Narumiya S, Sakaguchi S. (2019) Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T_reg cells by inhibition of CDK8/19. Science Immunol. 2019 Oct 25;4(40). pii: eaaw2707.doi:10.1126/sciimmunol.aaw2707.
26. Otaka F, Ito Y, Inoue T, Ohkubo H, Nishizawa N, Kojo K, Betto T, Yamane S, Narumiya S, Koizumi W, Majima M. (2019) Thromboxane A₂ receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury. Toxicol Appl Pharmacol. 15;381:114733. doi: 10.1016/j.taap.2019.114733. Epub 2019 Aug 27
27. Miyata H, Imai H, Koseki H, Shimizu K, Abekura Y, Oka M, Kawamata T, Matsuda T, Nozaki K, Narumiya S, Aoki T. (2019) Vasa vasorum formation is associated with rupture of intracranial aneurysms. Neurosurg. 2019 Aug 16:1-11. doi: 10.3171/2019.5.JNS19405. [Epub ahead of print] PMID: 31419795
28. Wong JH, Shigemizu D, Yoshii Y, Akiyama S, Tanaka A, Nakagawa H, Narumiya S, Fujimoto A. (2019) Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population. Genome Med. 11(1), 44. doi: 10.1186/s13073-019-0656-4. PMID: 31340865
29. Aoki T, Koseki H, Miyata H, Itoh M, Kawaji H, Takizawa K, Kawashima A, Ujiie H, Higa T, Minamimura K, Kimura T, Kasuya H, Nozaki K, Morita A, Sano H, Narumiya S. (2019) RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms. Rep. 2019 Jul 17;9(1):10387. doi: 10.1038/s41598-019-46886-2. PMID:31316152
30. Sawada, Y., Honda, T., Nakamizo, S., Nakajima, S., Nonomura, Y., Otsuka, A., Egawa, G., Yoshimoto, T., Nakamura, M., Narumiya, S. & Kabashima, K. (2019) Prostaglandin E₂(PGE₂)-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression. J Allergy Clin Immunol. 144(5):1265-1273.e9. doi: 10.1016/j.jaci.2019.06.036. Epub 2019 Jul 11. PMID:31301371
31. Kashiwagi H, Yuhki KI, Imamichi Y, Kojima F, Kumei S, Tasaki Y, Narumiya S, Ushikubi F. (2019) Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice. Thromb Haemost., 119(8), 1311-1320. doi: 10.1055/s-0039-1688906. Epub 2019 May 26. PMID: 31129913
32. Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T. (2019) Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation. Stroke Res. 2019 Feb 8. doi: 10.1007/s12975-019-0690-y. [Epub ahead of print] PMID: 30737656
33. Aida-Yasuoka, K., Nishimura, N., Fujisawa, N., Endo, N., Narumiya, S. & Tohyama, C. (2019) The role of prostaglandin E₂ receptor EP1 in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced neonatal hydronephrosis in mice. Toxicology, 415, 10-17. doi: 10.1016/j.tox.2019.01.006. Epub 2019 Jan 11. PMID: 30641090
34. Miyata, H., Shimizu, K., Koseki, H., Abekura, Y., Kataoka, H., Miyamoto, S., Nozaki, K., Narumiya, S. & Aoki, T. (2019) Real-time Imaging of an Experimental Intracranial Aneurysm in Rats. Neurol Med Chir (Tokyo), 59(1), 19-26. doi: 10.2176/nmc.oa.2018-0197. Epub 2018 Dec 15. PMID: 30555120
35. Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. (2019) Ligand binding to human prostaglandin E receptor EP₄at the lipid-bilayer interface. Chem. Biol., 15,18-26. doi: 10.1038/s41589-018-0131-3.
36. Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. (2019) Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. Nat. Chem. Biol., 15, 8-10. doi: 10.1038/s41589-018-0171-8.
37. Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S. (2018) LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. J. Invest., 2018 Nov 14. pii: S0022-202X(18)32815-X. doi: 10.1016/j.jid.2018.10.034.
38. Sakamoto S, Thumkeo D, Ohta H, Zhang Z, Huang S, Kanchanawong P, Fuu T, Watanabe S, Shimada K, Fujihara Y, Yoshida S, Ikawa M, Watanabe N, Saitou M, Narumiya S. (2018) mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility. PLoS Biol., 16, e2004874. doi: 10.1371/journal.pbio.2004874.
39. Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, Mimori-Kiyosue Y, Kakizuka A, Narumiya S, & Furuyashiki T. (2018) The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation. Neuron, 99(3):464-479. pii: S0896-6273(18)30531-2. doi: 10.1016/j.neuron.2018.06.035.
40. Higashida S, Nagai H, Nakayama K, Shinohara R, Taniguchi M, Nagai M, Hikida T, Yawata S, Ago Y, Kitaoka S, Narumiya S, & Furuyashiki T. (2018) Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Sci. Rep. 2018 Jul 11;8(1):10454. doi: 10.1038/s41598-018-28803-1.
41. Lee J, Aoki T, Thumkeo D, Siriwach R, Yao C, & Narumiya S. (2018) T cell-intrinsic prostaglandin E₂-EP2/EP4 signaling is critical in pathogenic T_H17 cell-driven inflammation. (2019) Allergy Clin. Immunol., 143(2):631-643. pii: S0091-6749(18)30896-0. doi: 10.1016/j.jaci.2018.05.036.
42. Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. (2018) Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Mol. Genet. 27(18):3165-3176. doi: 10.1093/hmg/ddy219.
43. Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K. (2018) Thromboxane A₂ facilitates IL-17A production from Vγ4₊ γδ T cells and promotes psoriatic dermatitis in mice. J. Allergy Clin. Immunol., 142(2):680-683. pii: S0091-6749(18)30562-1. doi: 10.1016/j.jaci.2018.01.054.
44. Kumei, S., Yuhki, K.I., Kojima, F., Kashiwagi, H., Imamichi, Y., Okumura, T., Narumiya, S. & Ushikubi, F. (2017) Prostaglandin I₂ suppresses the development of diet-induced nonalcoholic steatohepatitis in mice. FASEB J., 2017 Dec 15. pii: fj.201700590R. doi: 10.1096/fj.201700590R. [Epub ahead of print] PMID: 29247122
45. Emori, T., Hirose, J., Ise, K., Yomoda. J.I., Kasahara, M., Shinkuma, T., Yoshitomi, H., Ito, H., Hashimoto, M., Sugahara, S., Fujita, H., Yamamoto, N., Morita, Y., Narumiya, S. & Aramori, I. (2017) Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. J. Immunol. 2017 Nov 15;199(10):3427-3436. doi: 10.4049/jimmunol.1700941. Epub 2017 Oct 16. PMID: 29038247
46. Shinohara, R., Taniguchi, M., Ehrlich, A.T., Yokogawa, K., Deguchi, Y., Cherasse, Y., Lazarus, M., Urade, Y., Ogawa, A., Kitaoka, S., Sawa, A., Narumiya, S. & Furuyashiki, T. (2017) Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol. Psychiatry, 2017 Sep 19. doi: 10.1038/mp.2017.177. [Epub ahead of print] PMID: 28924188
47. Aoki, T., Saito, M., Koseki, H., Tsuji, K., Tsuji, A., Murata, K., Kasuya, H., Morita, A., Narumiya, S., Nozaki, K.; MR Macrophage Imaging Study Investigators. (2017) Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients. J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2055-2064. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.026. Epub 2017 Jul 31. PMID: 28774792
48. Ota, H., Katanosaka, K., Murase, S., Furuyashiki, T., Narumiya, S. & Mizumura, K. (2017) EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. J. Med. Sci. Sports, 2017 Jul 31. doi: 10.1111/sms.12954. [Epub ahead of print] PMID: 28759126
49. Vijay, R., Fehr, A.R., Janowski, A.M., Athmer, J., Wheeler, D.L., Grunewald, M., Sompallae, R., Kurup, S.P., Meyerholz, D.K., Sutterwala, F.S., Narumiya, S. & Perlman, S. (2017) Virus-induced inflammasome activation is suppressed by prostaglandin D₂/DP1 signaling. Proc. Natl. Acad. Sci. U. S. A., 2017 Jul 3;114(27):E5444-E5453. doi: 10.1073/pnas.1704099114. Epub 2017 Jun 19. PMID: 28630327
50. Robb, C.T., McSorley, H.J., Lee, J., Aoki, T., Yu, C., Crittenden, S., Astier, A., Felton, J.M., Parkinson, N., Ayele, A., Breyer, R.M., Anderton, S.M., Narumiya, S., Rossi, A.G., Howie, S.E., Guttman-Yassky, E., Weller, R.B. & Yao, C. (2017) Prostaglandin E₂ stimulates adaptive IL-22 production and promotes allergic contact dermatitis. J. Allergy Clin. Immunol., 2017 Jun 3. pii: S0091-6749(17)30914-4. doi: 10.1016/j.jaci.2017.04.045. [Epub ahead of print] PMID: 28583370
51. Ouhaddi, Y., Nebbaki, S.S., Habouri, L., Afif, H., Lussier, B., Kapoor, M., Narumiya, S., Pelletier, J.P., Martel-Pelletier, J., Benderdour, M. & Fahmi, H. (2017) Exacerbation of Aging-Associated and Instability-Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D₂ Receptor. Arthritis Rheumatol., 69, 1784-1795. doi: 10.1002/art.40160. Epub 2017 Aug 1. PMID: 28544596
52. Yamamoto, R., Aoki, T., Koseki, H., Fukuda, M., Hirose, J., Tsuji, K., Takizawa, K., Nakamura, S., Miyata, H., Hamakawa, N., Kasuya, H., Nozaki, K., Hirayama, Y., Aramori, I. & Narumiya, S. (2017) A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration. Br. J. Pharmacol., 174, 2085-2101. doi: 10.1111/bph.13820. Epub 2017 May 27. PMID: 28409823
53. Loo, T.M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M.M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara, E. & Ohtani, N. (2017) Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov. 7, 522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15. PMID: 28202625
54. Aoki, T., Frȍsen, J., Fukuda, M., Bando, K., Shioi, G., Tsuji, K., Ollikainen, E., Nozaki, K., Laakkonen, J. & Narumiya, S. (2017) Prostaglandin E₂-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Science Signal., 10(465). pii: eaah6037. doi: 10.1126/scisignal.aah6037.
55. Miyata H, Koseki H, Takizawa K, Kasuya H, Nozaki K, Narumiya S, Aoki T. T cell function is dispensable for intracranial aneurysm formation and progression. PLoS One. 2017 Apr 24;12(4):e0175421. doi: 10.1371/journal.pone.0175421. eCollection 2017. PMID: 28437485
56.  Kawano, Y., Fukui, C., Shinohara, M., Wakahashi, K., Ishii, S., Suzuki, T., Sato, M., Asada, N., Kawano, H., Minagawa, K., Sada, A., Furuyashiki, T., Uematsu, S., Akira, S., Uede, T., Narumiya, S., Matsui, T. & Katayama, Y. (2016) G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. Blood, 129, 587-597.
57. Deguchi, Y., Harada, M., Shinohara, R., Lazarus, M., Cherasse, Y., Urade, Y., Yamada, D., Sekiguchi, M., Watanabe, D., Furuyashiki, T. & Narumiya, S. (2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Rep., 17, 2405-2417.
58. Hosono, K., Isonaka, R., Kawakami, T., Narumiya, S. & Majima, M. (2016) Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. PLoS One, 11, e0162532.
59. Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. & Yanagita, M. (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight, 1, e87680.
60. Amano, H., Nakamura, M., Ito, Y., Kakutani, H., Eshima, K., Kitasato, H., Narumiya, S. & Majima, M. (2016) Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia. J. Surg. Res., 204, 153-163.
61. Ikezoe, K., Oga, T., Honda, T., Hara-Chikuma, M., Ma, X., Tsuruyama, T., Uno, K., Fuchikami, J., Tanizawa, K., Handa, T., Taguchi, Y., Verkman, A. S., Narumiya, S., Mishima, M. & Chin, K. (2016) Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep., 6, 25781.
62. Aoki, T., Yamamoto, K., Fukuda, M., Shimogonya, Y., Fukuda, S. & Narumiya, S. (2016) Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm. Acta Neuropathol. Commun., 4, 48.
63. Andoh, T., Yamamoto, A., Haza, S., Yuhki, K.I., Ushikubi, F., Narumiya, S. & Kuraishi, Y. (2016) Thromboxane A2 is Involved in Itch-associated Responses in Mice with Atopic Dermatitis-like Skin Lesions. Acta Derm. Venereol., 296, 899-904.
64. Duffin, R., O’Connor, R. A., Crittenden, S., Forster, T., Yu, C., Zheng, X., Smyth, D., Robb, C. T., Rossi, F., Skouras, C., Tang, S., Richards, J., Pellicoro, A., Weller, R. B., Breyer, R. M., Mole, D. J., Iredale, J. P., Anderton, S. M., Narumiya, S., Maizels, R. M., Ghazal, P., Howie, S. E., Rossi, A. G. & Yao, C. (2016) Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science, 351, 1333-1338.
65. Fujita, T., Soontrapa, K., Ito, Y., Iwaisako, K., Moniaga, C.S., Asagiri, M., Majima, M., & Narumiya, S. (2016) Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis. Hepatology, 63, 1325-1339.
66. Ma, X., Aoki, T., & Narumiya, S. (2016) Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways. Cell. Mol. Immunol., 13, 240-250.

Reviews

1. Yao C, Narumiya S. (2018) Prostaglandin-cytokine crosstalk in chronic inflammation. Br. J., 176(3):337-354. doi: 10.1111/bph.14530.
2. Narumiya, S. & Thumkeo, D. (2018) Rho signaling research: history, current status and future directions. FEBS Lett., 592, 1763-1776.
3. Aoki T, Yamamoto R, Narumiya S. (2018) Targeting macrophages to treat intracranial aneurysm. Oncotarget, 8, 104704-104705. doi: 10.18632/oncotarget.21368. eCollection 2017 Dec 1.

Book Chapter

1. Narumiya, S., Yokomizo, T. & Aoki, J. (2018) Lipid mediators and inflammation. In “Inflammation; From Molecular and Cellular Mechanisms to the Clinic” (Cavaillon, J.-M., and Singer, M., Eds), pp.651-694. Wiley-VCH

Invited Lectures

1. Narumiya, S.: 腫瘍微小環境のトランスレーション・リバーストランスレーション研究への薬理学的アプローチ, 第96回日本薬理学会年会（Yokohama）特別講演, December 1, 2022
2. Narumiya, S.: Prostaglandin-Cytokine Crosstalk in Chronic and Immune Inflammation. The JPS-BPS Joint Symposium on “Inflammation and immunity; new drug discovery opportunities”, December 11, 2017, London.
3. Narumiya, S.: Regulation of Stress Behavior by Prostaglandin E2/EP1-Dopamine/D1 Axis. The International Symposium on “Discovery of New Therapeutic Targets”, November 23, 2017, Daegu, Korea
4. Narumiya, S.: Structure and Drug Discoveries in the Kyoto University-Astellas Pharma Project. ITMAT (Institute of Translational Medicine and Therapeutics) 2017 Symposium. October 16, 2017, Philadelphia.

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Original Articles

1. Yuki Yamawaki, Md Sorwer Alam Parvez, Yayoi Wada et al. Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum, 21 February 2023, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2555653/v1]
2. Ohtsuki G, Kim T, Sun P, Chen Y, Ugo D’Angelo E. Editorial: Cerebellum-related learning and psychiatric diseases. Front Cell Neurosci. 2023 Feb 13;17:1132286. doi: 10.3389/fncel.2023.1132286. PMID: 36860375; PMCID: PMC9969138.
3. Hikosaka M, Kawano T, Wada Y, Maeda T, Sakurai T, Ohtsuki G. Immune-Triggered Forms of Plasticity Across Brain Regions. Front Cell Neurosci. 2022 Jul 22;16:925493. doi: 10.3389/fncel.2022.925493. PMID: 35978857; PMCID: PMC9376917.
4. Parvez MSA, Ohtsuki G. Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology. Brain Sci. 2022 Mar 10;12(3):367. doi: 10.3390/brainsci12030367. PMID: 35326323; PMCID: PMC8946185.
5. Yamawaki Y, Wada Y, Matsui S, Ohtsuki G. Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex. Curr Res Neurobiol. 2022 Feb 5;3:100028. doi: 10.1016/j.crneur.2022.100028. PMID: 36518339; PMCID: PMC9743057.
6. Parvez MSA, Saha MK, Ibrahim M, Araf Y, Islam MT, Ohtsuki G, Hosen MJ. Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics. Immun Inflamm Dis. 2022 Jul;10(7):e639. doi: 10.1002/iid3.639. PMID: 35759231; PMCID: PMC9210926.
7. Yayoi Wada, Hirohiko Imai, Yuki Yamawaki, Md Sorwer Alam Parvez, Sae Matsui, Gen Ohtsuki. High permeability of the CSF flow in the juvenile mouse brain by brain-wide DCE-MRI. bioRxiv 2021.09.21.461189; doi: https://doi.org/10.1101/2021.09.21.461189
8. Akitoshi Ozaki, Yuki Yamawaki, Gen Ohtsuki. Psychosis symptoms following aberrant immunity in the brain. Neural Regeneration Research, 16(3):512-513. doi: 10.4103/1673-5374.293148. Mar 2021.
9. Kohei Segawa, Yukari Blumenthal, Yuki Yamawaki, Gen Ohtsuki. A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms. Biology, 10(1), 34; doi.org/10.3390/biology10010034. 13 Jan 2021.
10. Gen Ohtsuki, Mari Shishikura, Akitoshi Ozaki.　 Synergistic excitability plasticity in cerebellar functioning.　 The FEBS Journal,;287(21):4557-4593. doi: 10.1111/febs.15355. Nov 2020.
11. Gen Ohtsuki, Yuki Yamawaki, Kousuke Tanigaki. プルキンエ細胞興奮性の可塑性. 『生体の科学』特集 小脳研究の未来　 (公財) 金原一郎医学医療振興財団. 2021

Presentations at Academic Conferences／Symposiums

(Oral Presentation)

1.  [Invited] *Gen Ohtsuki. Environmental stress insults in 2HIT model synergistically produce reactive microglia and DAM^IMCs in the cerebellum. Hamburg University – Kyoto University joint symposium, “Cellular mechanism of learning and memory” on March 13-14, 2023 (Kyoto University Campus). Organizers: Profs. Thomas Oertner, Michael Kreutz, and Yasunori Hayashi. (3.13-14.2023)

2. [Invited] *Gen Ohtsuki. Immune-triggered excitability plasticity and cerebellar psychiatric disease models. SY06-01 New perspectives on the cerebellar functions. Keiko Tanaka-Yamamoto (Korea Institute of Science and Technology), Sang Jeong Kim (Seoul National University), Yong-Seok Lee (Seoul National University), Gen Ohtsuki (Kyoto University). The 25th Annual Meeting of The Korean Society for Brain and Neural Sciences (KSBNS 2022) (Incheon, Seoul, KR, 2022, May 19-21) (5.20.2022)
3. *Gen Ohtsuki. Plasticity of the intrinsic excitability in the acute inflammation and psychiatric disease models. 第99回日本生理学大会 (Sendai 2022, Mar 16-18) (3.16.2022)
4. *Gen Ohtsuki, Yuki Yamawaki, Yayoi Wada. Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex. 第１１３回近畿生理学談話会 (京都府立医科大学 2021, Nov 27) (11.27.2021)
5. [Invited] *Gen Ohtsuki. Intrinsic plasticity of the Purkinje-cell dendrites and immune stress. 1st China, Japan, and Korea (CJK) symposium・第44回日本神経科学大会 1st China-Japan-Korea International Meeting and 44th Annual Meeting of the Japan Neuroscience Society (Kobe 2021, July 28-31) (7.30.2021)
6. *Gen Ohtsuki. Multiple environmental stress during an immature state exacerbates psychiatric diseases via microglia and vasculature. 第2回医薬系研究交流サロン (Kyoto University Graduate Program for Medical Innovation)  (4.19.2021-4.20.2021)

 

(Poster Presentation)

1. *Momoka Hikosaka, Md Sorwer Alam Parvez, Yayoi Wada, Yuki Yamawaki, and Gen Ohtsuki. Molecular signal characterisation of disease-associated immune cells by single-cell proteomics using highly multiplexed imaging mass cytometry in the cerebellum of psychiatric disorder models via developmental complex inflammatory stress. 第45回日本分子生物学会年会. (11.30.2022-12.02.2022)

2. Md Sorwer Alam Parvez, Momoka Hikosaka, Yayoi Wada, Yuki Yamawaki, and Gen Ohtsuki. Single-cell spatial proteomics using highly multiplexed imaging mass cytometry across brain regions in psychiatric disorder models by complex biological stresses during development. 第45回日本分子生物学会年会. (11.30.2022-12.02.2022)

3. *Gen Ohtsuki, Yuki Yamawaki, Hirohiko Imai, Soichi Oe, and Yukie Hirahara. Correlation of whole-brain activity of immune-stress induced psychiatric disease models. 第44回日本神経科学大会(Kobe 2021, July 28-31) 2P-119. (7.28.2021-7.31.2021)
4. *Yayoi Wada, Hirohiko Imai, Yuki Yamawaki, and *Gen Ohtsuki. Functional maturation of the vasculature system of mouse brain during development. 第44回日本神経科学大会(Kobe 2021, July 28-31) 4P-174. (7.28.2021-7.31.2021)
5. *Yuki Yamawaki, Gen Ohtsuki, and Takeshi Sakurai. Onset of psychiatric-disease spectrum through a combination of embryonic and developmental inflammatory stresses. 第44回日本神経科学大会(Kobe 2021, July 28-31) 4P-436. (7.28.2021-7.31.2021)
6. *Yuki Yamawaki, Takeshi Sakurai, and Gen Ohtsuki. Onset of psychiatric-disease spectrum through a combination of embryonic and developmental inflammatory stresses. 第2回医薬系研究交流サロン(Kyoto University Graduate Program for Medical Innovation)  (4.19.2021-4.20.2021)
7. *Hirohiko Imai, Yuki Yamawaki and *Gen Ohtsuki. Functional maturation of brain vasculature system in mouse development. 第2回医薬系研究交流サロン(Kyoto University Graduate Program for Medical Innovation)  (4.19.2021-4.20.2021)
8. Yuki Yamawaki and *Gen Ohtsuki. Endotoxin-induced hypoexcitability plasticity of layer 5 pyramidal neurons in the medial prefrontal cortex. 第2回医薬系研究交流サロン(Kyoto University Graduate Program for Medical Innovation)  (4.19.2021-4.20.2021)
9. Yuki Yamawaki, Gen Ohtsuki. Endotoxin-induced hypoexcitability plasticity of layer 5 pyramidal neurons in the medial prefrontal cortex. (Poster Presentation). 第126回日本解剖学会総会･全国学術集会・第98回日本生理学会大会. 日本解剖学会・日本生理学会合同大会 (3.28.2021-3.30.2021)

Reviewer experience of international journals

1. eLife
2. International Journal of Molecular Sciences x2
3. Journal of Neuroinflammation x3
4. Journal of Chemical Neuroanatomy
5. Journal of Pediatric Neurology
6. Neuroscience
7. Scientific Reports
8. Trends in Neurosciences

 

Conference

1. Councilor, The Japan Neuroscience Society  (February 2023)

Editorial Board Membership

1. 2022-Current

   Editorial Board Member “Frontiers in Cellular Neuroscience”, Frontiers, 1005 Lausanne, Switzerland.

2. 2021-2022

   Guest Associate Editor in Cellular Neurophysiology of “Frontiers in Cellular Neuroscience”, Frontiers, 1005 Lausanne, Switzerland.

   Research Topic: Cerebellum-Related Learning and Psychiatric Diseases

   https://www.frontiersin.org/research-topics/27560/cerebellum-related-learning-and-psychiatric-diseases#articles

3. 2020-2022
   Editorial Board Member (Journal Topic Board) of “biology”, MDPI, Founded in Basel, Switzerland.

Doctor’s Degree

• Yuki Yamawaki　　

Collaborative Research

• 5 projects　　(Kansai Medical University, Doshisha University, Gunma University, Standard Biotools, Takeda Pharmaceutical Company Limited.)

Book Chapter

1. Chikako Saotome, 山下 晃男. “京都大学における共同研究、受託研究の進め方と契約のポイント”, 共同研究開発の進め方、契約のポイント, 184-194 (2020), 技術情報協会
2. Chikako Saotome. “知的財産マネジメント”, 整形外科, 71, pp.668-673 (2020)

Papers

1. Seki Kiyoshi, Hiroshi Suzuki, Seiji Abe and Chikako Saotome, “Lifecycle management of orphan drugs approved in Japan.” Orphanet J. Rare Dis., 17, 299 (2022)
2. Chikako Saotome. バイオベンチャーの事業における特許出願の重要性, LES Japan News, 58, 46-54 (2017)

Presentations at Academic Conferences／Symposiums

1. Chikako Saotome, Wataru Morishita, Takayama Kojiro「日米欧中におけるデジタルヘルス分野の特許出願に関する調査研究」 第 20 回日本知財学会学術集会（ 11.5-6, 2022）
2. Chikako Saotome, Kiyoshi Seki, Hiroshi Suzuki, Seiji Abe. 「日本における希少疾病用医薬品のライフサイクルマネジメント」 第 19 回日本知財学会学術集会（ 11.27.2021 – 11.28.2021）
3. Chikako Saotome, Kiyoshi Seki, Hiroshi Suzuki, Seiji Abe. 「日本における希少疾病用医薬品のライフサイクルマネジメント」 第 36 回研究イノベーション学会学術集会（10.30.2021 – 10.31.2021）
4. Chikako Saotome. 米国バイオベンチャーの特許出願に関する調査研究.  第17回日本知財学会学術研究発表会, December 2019
5. Chikako Saotome. 利益相反への対応について -WhyとHow toについて事例を交えて解説します-. 第66回日本栄養改善学会学術総会, September 2019 (Invited Lecture)
6. Chikako Saotome. 米国バイオベンチャーのアライアンス戦略に関する検討. 日本知財学会第１６回学術研究発表会, December 2018
7. Chikako Saotome. 組織的共同研究における出口戦略ーAKプロジェクトの事例ー. 研究・イノベーション学会第３３回年次学術集会, October 2018
8. 鍾 亦琳, Chikako Saotome. バイオシミラーの特許出願の調査研究. The 14th Annual Research Presentation of Intellectual Property Association of Japan, December 2016
9. Chikako Saotome. 米国バイオベンチャーの特許出願の調査研究. The 14th Annual Research Presentation of Intellectual Property Association of Japan, December 2016

Awards & Others

1. 令和元年度　東邦大学額田奨学金受賞 (2019)
2. Chikako Saotome, Yutaka Teranishi, Shuh Narumiya. 学の視点　アカデミアでの創薬シーズと人材のインキュベーション　—京都大学の取り組みを例にー. 実験医学, 35, 485-490 (2017), February 2017
3. Chikako Saotome. 企業との組織的包括的産学連携の進め方と知財マネジメント. （株）技術情報協会「オープンイノベーションによる新事業創出、早期事業化とその実践事例」, pp331-337, January 2017

Papers（peer-reviewed）

1. Siriwach R, Ngo AQ, Narumiya S, Thumkeo D. An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis. STAR Protocols, 3:101906, 2022.
2. Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S. PGE₂-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment. Cell Reports, 39:110914, 2022.
3. Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2118816119. doi: 10.1073/pnas.2118816119. Epub 2022 Apr 8. PMID: 35394866; PMCID: PMC9169816.
4. Siriwach R, Ngo AQ, Higuchi M, Arima K, Sakamoto S, Watanabe A, Narumiya S, Thumkeo D. Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience. 2022 Mar 21;25(4):104130. doi: 10.1016/j.isci.2022.104130. PMID: 35391830; PMCID: PMC8980802.
5. Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen YH, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, López-Giráldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT. DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease. JAMA Neurol. 2021 Aug 1;78(8):993-1003. doi: 10.1001/jamaneurol.2021.1681. PMID: 34125151; PMCID: PMC8204259.
6. Thumkeo D, Narumiya S. Opening the door to better aspirin, Structure 29: 200-202, 2021.
7. Abe I, Terabayashi T, Hanada K, Kondo H, Teshima Y, Ishii Y, Miyoshi M, Kira S, Saito S, Tsuchimochi H, Shirai M, Yufu K, Arakane M, Daa T, Thumkeo D, Narumiya S, Takahashi N, Ishizaki T. Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction. Cardiovasc Res: cvaa206, 2020.
8. Schneider R, Deutsch K, Hoeprich GJ, Marquez J, Hermle T, Braun DA, Seltzsam S, Kitzler TM, Mao Y, Buerger F, Majmundar AJ, Onuchic-Whitford AC, Kolvenbach CM, Schierbaum L, Schneider S, Halawi AA, Nakayama M, Mann N, Connaughton DM, Klämbt V, Wagner M, Riedhammer KM, Renders L, Katsura Y, Thumkeo D, Soliman NA, Mane S, Lifton RP, Shril S, Khokha MK, Hoefele J, Goode BL, Hildebrandt F. DAAM2 variants cause nephrotic syndrome via actin dysregulation. Am J Hum Genet: 107, 1113-1128, 2020.
9. Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel  MF, Narumiya S. mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse, Science Advances , 6 (1), eaay2432, 2020.
10. Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S. Lysophosphatidic acid facilitates human keratinocyte differentiation through the LPAR1/LPAR5-RHO-ROCK-SRF axis and promotes skin barrier function. Journal of Investigative Dermatology, in press
11. Lee J, Aoki T, Thumkeo D, Siriwach R, Yao C, Narumiya S. T cell intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic Th17 cell-driven inflammation. Journal of Allergy and Clinical Immunology 143(2), 631-643, 2019
12. Sakamoto S, Thumkeo D, Ohta H, Zhang Z, Kanchanawong P, Fuu T, Watanabe S, Fujihara Y, Ikawa M, Watanabe N, Saitou M, Narumiya S. mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility. PLoS Biology 16(9): e2004874, 2018
13. Narumiya S, Thumkeo D. Rho signaling research: history, current status and future directions, FEBS Letters 592(11): 1763-1776, 2018
14. Ueyama T, Ninoyu Y, Nishio S, Miyoshi T, Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D, Sakaguchi H, Watanabe N, Usami S, Saito N, Kitajiri S.
    Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss.
    EMBO Molecular Medicine 8(11) 1310-1324, DOI 1015252/emmm.201606609, November 2016

Presentations at Academic Conferences／Symposiums

1. Dean Thumkeo. Elucidation of prostaglandin E2-dependent cancer immune evasion mechanism by scRNA-seq analysis. 3^rd 10x Genomics Journal Club. Kyoto (online), Japan, 19^th January 2023, Oral Presentation.
2. Dean Thumkeo. Open up the next generation pharmacology with scRNA-seq technology ~elucidation of the role of PGE₂-EP2/4 pathway in cancer immunity as an example~. The 24^th Japan-Korea Joint Seminar on Pharmacology, Yokohama, Japan, 3^rd December 2022, Symposium.
3. Dean Thumkeo, Siwakorn Punyawatthananukool, Shuh Narumiya. Inhibition of PGE₂-EP2/EP4 signaling elicits anti-tumor immunity through the suppression of mregDC-Treg axis in inflammatory tumor microenvironment. The 96^th Annual Meeting of the Japanese Pharmacological Society. Yokohama, Japan, 1^st December 2022, Symposium.
4. Ryuma Matsuura, Dean Thumkeo, Shuh Narumiya. Activation of regulatory T cells through PGE₂-EP4 signaling. The 96^th Annual Meeting of the Japanese Pharmacological Society. Yokohama, Japan, 1^st December 2022, Oral Presentation.
5. Dean Thumkeo. scRNA-seq technology and next generation pharmacology ~elucidating roles of PGE₂ in cancer immunity as an example~. Departmental Seminar, Department of Biochemistry, Mahidol University Faculty of Science, Bangkok, Thailand, 7^th November 2022, Invited Seminar.
6. Dean Thumkeo, Siwakorn Punyawatthananukool, Varodom Charoensawan, Shuh Narumiya. Elucidation of the role of PGE₂-EP2/4 pathway in cancer immunity utilizing scRNA-seq technology. The Human Cell Atlas 2022 Asia meeting, Bangkok, Thailand, 4^th November 2022, Symposium
7. Dean Thumkeo. Elucidation of the immune suppression mechanism of PGE₂-EP2/EP4 signaling in LLC1 mouse tumor model. The 81^st Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 29^th September 2022, Poster Presentation.

8. Thumkeo Dean, Narumiya Shuh. PGE2 EP2/EP4 signaling mediates immunosuppression in tumor microenvironment through the facilitation of mregDC Treg axis. 第 50回日本免疫学会総会 , Workshop, Nara, 2021.

9. Ryuuma Matsuura, Thumkeo Dean, Shuh Narumiya. 制御性T 細胞に対するプロスタグランジンE2 の作用および分子制御機構の解明. 第140回日本薬理学会近畿部会, Oral Presentation, Nara, 2021.

10. Ngo Quynh Anh, Siriwach Ratklao, Dean Thumkeo, Shuh Narumiya. Single cell RNA sequencing identifies a novel LPA-induced THBS1-positive keratinocyte subpopulation that is involved in wound healing. 第138回日本薬理学会近畿部会, November 14, 2020, Osaka (Online)
11. Makio Higuchi, Dean Thumkeo, Shuh Narumiya. New compounds for atopic dermatitis promote selective AHR-induced Filaggrin transcription in NHEK cells. 第137回日本薬理学会近畿部会, June 20, 2020, Okayama (Online)
12. Dean Thumkeo, Yoshichika Katsura, Yukako Nishimura, Pakorn Kanchanawong, Naoki Watanabe, Matthew F. Krummel, Shuh Narumiya. mDia1/3 facilitate Lat phosphorylation by Zap70 via the spatiotemporal control of F-actin polymerization at the immune synapse.  ASCB EMBO 2019 meeting, Washington D.C., USA, 9th December 2019, Poster presentation
13. Dean Thumkeo. 生体内におけるアクチン重合因子mDiaの生理的機能の解明〜精子形成及びT細胞活性化を例に〜 大分大学医学部セミナー、大分、2019年11月7日、Oral presentation
14. Dean Thumkeo, Shuh Narumiya. LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPRA5-RHO-ROCK-SRF axis The 60th International Conference on the Bioscience of Lipids, Tokyo, Japan, 18th June 2019, Poster presentation
15. Kohei Tanabe, Dean Thumkeo, Shuh Narumiya. ゾホスファチジン酸(LPA)によるヒト表皮細胞の分化誘導及び皮膚バリア機能の促進。第134回日本薬理学会近畿部会, Kobe. November 23, 2018, Oral Presentation
16. Jinju Lee, Dean Thumkeo, Tomohiro Aoki, Chengcan Yao, Shuh Narumiya. IL-23 generates pathogenic Th17 cells by trigerring T cell-intrinsic prostaglandin E2-EP2EP4 signaling. The 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 5th July 2018, Poster presentation
17. Yoshichika Katsura, Dean Thumkeo, Shuh Narumiya. Indispensible role of formin-dependent cortical F-actin remodeling in TCR signaling. The 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 5th July 2018, Poster presentation
18. Kohei Tanabe, Dean Thumkeo, Ratklao Siriwach, Junken Aoki, Shuh Narumiya. Lysophosphatidic acid facilitates human keratinocyte differentiation through the LPAR1/LPRA5-Rho-ROCK-SRF axis and promotes skin barrier function. The 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 2nd July 2018, Poster presentation
19. Dean Thumkeo, Xiaojun Ma, Jinju Lee, Shuh Narumiya. Roles of prostaglandins E2-EP2 signaling in colitis-associated cancer model. 第45回内藤カンファレンス “Immunological and Molecular Bases for Cancer Immunotherapy”, Hokkaido. June 27, 2018, Poseter presentation
20. Yoshichika Katsura, Dean Thumkeo, Shuh Narumiya. アクチン制御タンパクforminのT細胞受容体シグナル伝達における昨日解析. 第133回日本薬理学会近畿部会,  Hiroshima. June 1, 2018, Oral Presentation
21. Kohei Tanabe, Dean Thumkeo, Ratklao Siriwach, Junken Aoki, Shuh Narumiya. ヒト表皮細胞のバリア機能におけるリゾホスファチジン酸(LPA)の役割解明. 第133回日本薬理学会近畿部会, Hiroshima. June 1, 2018, Oral Presentation
22. Dean Thumkeo, Shuh Narumiya. “Cortical F-actin meshwork in Sertoli cells is a structure in continuous with contractile F-actin bundles and dependent on formin activity” Joint Meeting for Biological Motility (Sponsored by Grant-in-Aid Scientific Research on Innovative Areas “Harmonized supramolecular motility machinery and its diveristy”), Tokyo, Japan, January 2018.
23. Dean Thumkeo, Satoko Sakamoto, Takayoshi Fu, Shuh Narumiya
    Roles of mDia, a rho effector and actin nucleator, in eye development.
    The 90th Annual Meeting of the Japanese Pharmacological Society. Nagasaki, Japan, March 2017, Poster presentation.

Awards & Others

1. 令和 3 年 Nikon JOICA Award 2020優秀賞
2. 令和 2 年 日本医師会医学研究奨励賞
3. Dean Thumkeo. Japanese Translation: p.78-90「6章 生体防御機構」& p.317-334「26章 抗炎症薬及び免疫抑制剤」. “Rang & Dale’s Pharmacology, 8th edition”  Supervision: Naoki Watanabe (Kyoto University).  Elsevier Japan, December 19, 2018.

 

Original Articles

(*Corresponding author, #Co-first author, Group member)

1. Miyazawa, K., Ito, K., Ito, M., Zou, Z., Kubota, M., Nomura, S., Matsunaga, H., Koyama, S., Ieki, H., Akiyama, M., Koike, Y., Kurosawa, R., Yoshida, H., Ozaki, K., Onouchi, Y., BioBank Japan Project, Takahashi, A., Matsuda, K., Murakami, Y., Aburatani, H., Kubo, M., Momozawa, Y., Terao, C., Oki, S., Akazawa, H., Kamatani, Y., Komuro, I. Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk. Nat Genet. 2023. Online ahead of print.
2. Iwata, M., Kosai, K., Ono, Y., Oki, S., Mimori, K., Yamanishi, Y. Regulome-based characterization of drug activity across the human diseasome. NPJ Syst Biol Appl. 8(1), 44, 2022.
3. Hino, Y., Nagaoka, K., Oki, S., Etoh, K., Hino, S., Nakao, M. Mitochondrial stress induces AREG expression and epigenomic remodeling through c-JUN and YAP-mediated enhancer activation. Nucleic Acids Res. 50(17), 9765-9779, 2022.
4. Hirata, H., Kamohara, A., Murayama, M., Nishioka, K., Honda, H., Urano, Y., Soejima, H., Oki, S., Kukita, T., Kawano, S., Mawatari, M., Kukita, A. A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation. J Cell Physiol. 237(10), 3912-3926, 2022.
5. Honda, M., Kimura, R., Harada, A., Maehara, K., Tanaka, K., Ohkawa, Y., Oki, S.* Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections. STAR Protoc. 3(2), 101346, 2022.
6. Zou, Z., Ohta, T., Miura, F., Oki, S.* ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data. Nucleic Acids Res. 50(W1), W175-W182, 2022.
7. Eguchi, R., Hamano, M., Iwata, M., Nakamura, T., Oki, S., Yamanishi, Y. TRANSDIRE: data-driven direct reprogramming by a pioneer factor-guided trans-omics approach. Bioinformatics. 38(10), 2839-2846, 2022.
8. Yamamoto-Imoto, H., Minami, S., Shioda, T., Yamashita, Y., Sakai, S., Maeda, S., Yamamoto, T., Oki, S., Takashima, M., Yamamuro, T., Yanagawa, K., Edahiro, R., Iwatani, M., So, M., Tokumura, A., Abe, T., Imamura, R., Nonomura, N., Okada, Y., Ayer, DE., Ogawa, H., Hara, E., Takabatake, Y., Isaka, Y., Nakamura, S., Yoshimori, T. Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Rep. 38(9), 110444, 2022.
9. Zou, Z., Iwata, M., Yamanishi, Y., Oki, S.* Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses. BMC Bioinform. 23(1), 51, 2022.
10. Kimura, R., Inoue, Y.U., Kikkawa, T., Tatehana, M., Morimoto, Y., Inada, H., Oki, S., Inoue, T., Osumi, N. Detection of REST expression in the testis using epitope‐tag knock‐in mice generated by genome editing. Dev Dyn. 251(3), 525-535, 2022.
11. Honda M, Kimura R, Harada A, Maehara K, Tanaka K, Ohkawa Y, Oki S. Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections. STAR Protoc. 2022 Apr 22;3(2):101346. doi: 10.1016/j.xpro.2022.101346. PMID: 35496796; PMCID: PMC9046621.
12. Z. Zou, T. Ohta, F. Miura, S. Oki*. (2022). ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq, and Bisulfite-seq data. Nucleic Acids Res. gkac199.
13. Z. Zou, M. Iwata, Y. Yamanishi*, S. Oki*. (2022). Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses. BMC Bioinformatics. 23(1), 51.
14. H. Yamamoto-Imoto, S. Minami, T. Shioda, Y. Yamashita, S. Sakai, S. Maeda, T. Yamamoto, S. Oki, et al. (2022). Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Rep. 38(9), 110444.
15. R. Kimura#, Y.U. Inoue#, T. Kikkawa#, M. Tatehana, Y. Morimoto, H. Inada, S. Oki, T. Inoue, N. Osumi. (2022). Detection of REST expression in the testis using epitope‐tag knock‐in mice generated by genome editing. Dev Dyn. 251(3), 525-535.
16. M. Honda#, S. Oki#*, R. Kimura, A. Harada, K. Maehara, K. Tanaka, C. Meno, Y. Ohkawa*. (2021). High-depth spatial transcriptome analysis by photo-isolation chemistry. Nat Commun. 12(1), 4416.
17. Pecori, F., Yokota, I., Hanamatsu, H., Miura, T., Ogura, C., Ota, H., Furukawa, J. ichi, Oki, S., Yamamoto, K., Yoshie, O., et al. (2021). A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition. S Rep. 11.
18. Yoshizaki, K., Kimura, R., Kobayashi, H., Oki, S., Kikkawa, T., Mai, L., Koike, K., Mochizuki, K., Inada, H., Matsui, Y., et al. (2021). Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF. EMBO Rep.
19. Hirayama, M., Wei, F.Y., Chujo, T., Oki, S., Yakita, M., Kobayashi, D., Araki, N., Takahashi, N., Yoshida, R., Nakayama, H., et al. (2020). FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression. Cell Rep. 31.
20. Miyamoto, Y., Sasaki, M., Miyata, H., Monobe, Y., Nagai, M., Otani, M., Whiley, P.A.F., Morohoshi, A., Oki, S., Matsuda, J., et al. (2020). Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse. FASEB J. 34, 16224–16242.
21. Kaminuma, E., Baba, Y., Mochizuki, M., Matsumoto, H., Ozaki, H., Okayama, T., Kato, T., Oki, S., Fujisawa, T., Nakamura, Y., et al. (2020). DDBJ data analysis challenge: A machine learning competition to predict arabidopsis chromatin feature annotations from DNA sequences. Genes Genet. Syst. 95, 43–50.

Book Chapter (English)

1. S. Oki, T. Ohta. (2021). ChIP Atlas. Practical Guide to Life Science Databases.

Book Chapter (Japanese)

1. Shinya Oki , Yasuyuki Ohkawa. 光単離化学による高深度かつ高解像度トランスクリプトーム解析. 生物物理. 62(6), 2022.
2. Shinya Oki , Yasuyuki Ohkawa. Photo-Isolation Chemistry: PIC法を用いた微小細胞集団での遺伝子発現解析. 月刊「細胞」. 54(10), 2022.
3. Mizuki Honda , Shinya Oki.  空間トランスクリプトミクス. 生物工学会誌. 100(6), 2022.
4. Mizuki Honda , Shinya Oki.「Photo-Isolation Chemistry：光照射による高解像度かつ高感度なトランスクリプトーム技術」 実験医学 . 39(14), 2021.
5. Shinya Oki , Yasuyuki Ohkawa.「概論：空間トランスクリプトーム技術の最前線」 実験医学 . 39(14), 2021 　Special Edition
6. Shinya Oki, Mizuki Honda　「局所的かつ高深度の空間トランスクリプトーム技術：Photo-Isolation Chemistry」　実験医学別冊. December 2020.

Presentations at Academic Conferences／Symposiums

1. Shinya Oki. 光単離化学（PIC）による局所的トランスクリプトーム解析. 第100回日本生理学会大会. 3/16/2023.（Invited）
2. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. 東北大学分子代謝病態学Webセミナー. 1/17/2023.（Invited）
3. Shinya Oki. Photo-Isolation Chemistryを用いた局所的なトランスクリプトーム解析. 第67回日本人類遺伝学会. 12/15/2022.（Invited）
4. Shinya Oki. 光単離化学による局所的かつ高深度のトランスクリプトーム解析. 第45回日本分子生物学会. 12/2/2022.（Invited）
5. Shinya Oki. Photo-isolation chemistryによる局所的高深度トランスクリプトーム解析. ExCELLS セミナー. 11/15/2022.（Invited）
6. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. NGS EXPO 2022. 10/19/2022.（Invited）
7. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. 東京慈恵会医科大学 医学研究の基礎を語り合う集い. 10/11/2022.（Invited）
8. Shinya Oki. Photo-isolation chemistryによる局所的高深度トランスクリプトーム解析. シングルセルゲノミクス研究会. 8/30/2022.（Invited）
9. Shinya Oki. データ駆動型解析による noncoding 病モデルマウスの作製. 株式会社セツロテック コラボWebセミナー. 8/4/2022.（Invited）
10. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. 第25回小児心血管分子医学研究会. 7/21/2022.（Invited）
11. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. 徳島大学 医学研究科セミナー. 7/6/2022.（Invited）
12. Shinya Oki. Photo-Isolation-Chemistry (PIC)：局所領域に対する高深度トランスクリプトーム解析. 京都大学 先端バイオメディシン解析技術室シンポジウム. 6/30/2022.（Invited）
13. Shinya Oki. Photo-isolation chemistry for high-resolution and deep spatial transcriptome with tissue sections. 第74回日本細胞生物学会大会. 6/29/2022.（Invited）
14. Shinya Oki. Data-driven and technical approaches to understand spatial gene regulation. 京都大学医学研究科・神経科学教育コース. 6/27/2022.（Invited）
15. Shinya Oki. 時空間的な遺伝子発現制御のしくみを探る. 第127回日本解剖学会年界. 3/27/2022.（Invited）
16. Shinya Oki. 時空間的な遺伝子発現制御のしくみを探る. 東京大学 理学系研究科 生物情報科学科・黒田研セミナー. 2/10/2022.（Invited）
17. Shinya Oki. Photo-Isolation-Chemistry (PIC)：局所的な高深度トランスクリプトーム解析. 基礎生物学研究所・新規モデル生物開発センター・テクニカルワークショップ. 2/1/2022.（Invited）
18. Shinya Oki. 光単離化学(PIC)による高解像度かつ高深度の空間オミクス解析. JST-CRDS 俯瞰ワークショップ. 1/20/2022.（Invited）
19. Shinya Oki. ChIP-Atlas update: Bisulfite-seqとATAC-seqデータを統合. 第44回日本分子生物学会年会. 12/2/2021.（Invited）
20. Shinya Oki. Data-driven and technical approaches to understand spatial gene regulation. 奈良先端大学院大学講義「バイオサイエンスにおけるビッグデータ」. 11/30/2021.（Part-time Lecturer）
21. Shinya Oki. 時空間的な遺伝子発現制御のしくみを探る. JST・理研共催 バイオDXシンポジウム. 11/22/2021.（Invited）
22. Shinya Oki. Data-driven and technical approaches to understand spatial gene regulation. 熊本大学リエゾンラボ研究会・HIGO最先端研究セミナー. 10/13/2021.（Invited）
23. Shinya Oki. Data-driven and technical approaches to understand spatial gene regulation. 京都大学医学研究科・神経科学教育コース. 9/27/2021.（Invited）
24. Shinya Oki. 時空間的な遺伝子発現制御のしくみを探る. 日本生物工学会東日本支部 生物工学フォーラム. 8/27/2021.（Invited）
25. Shinya Oki. 空間的な遺伝子発現制御のしくみを探る. 第85回日本循環器学会学術集会. 3/27/2021.（Invited）
26. Shinya Oki, Data-driven and technical approaches to understand spatial gene regulation, 第43回日本分子生物学会年会, 12/3/2020. (Invited)
27. Shinya Oki, ChIP-Atlas: 公共 ChIP-seq データを利活用できる, 第43回日本分子生物学会年会, 12/2/2020. (Invited)
28. Shinya Oki, ChIP-seqビッグデータを統合解析し、薬剤の作用機序解明に迫る, 京都大学「医学領域」産学連携推進機構/一般社団法人芝蘭会 産学情報交流会. 9/10/2020. (Invited)
29. Shinya Oki, ChIP-Atlas の使い方と使われ方, 第9回生命医薬情報学連合大会 (IIBMP2020), 9/3/2020. (Invited)
30. Shinya Oki, 空間的な遺伝子発現制御のしくみを探る, 第9回生命医薬情報学連合大会 (IIBMP2020), 9/2/2020. (Invited)

 

Original Articles （peer-reviewed）

1. Hoshino T, Liu M-W, Wu K-A, Tsuruyama T, Komura S. Pattern formation of skin cancers: Effects of cancer proliferation and hydrodynamic interactions. Physical Review E , 2019 (in press).
2. Yoshinari Nakatsuka, Tomohiro Handa, Ran Nakashima, Kiminobu Tanizawa, Takeshi Kubo, Yuko Murase, Akihiko Sokai, Kohei Ikezoe, Yuji Hosono, Kizuku Watanabe, Shinsaku Tokuda, Kazuko Uno, Akihiko Yoshizawa, Tatsuaki Tsuruyama, Ryuji Uozumi, Sonoko Nagai, Kazuhiro Hatta, Yoshio Taguchi, Michiaki Mishima, Kazuo Chin, Tsuneyo Mimori, Toyohiro Hirai. Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease. Rheumatology, 2019 (in press).
3. Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Shigeo Takaishi, Haruhiko Akiyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Chiba T, and Seno H. Arid1a is essential for  intestinal stem cells through Sox9 regulation. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713.
4. Nigmet Y, Hata K, Tamaki I, Okamura Y, Tsuruyama T, Miyauchi H, Kusakabe J, Tajima T, Hirao H, Kubota T, Inamoto O, Yoshikawa J, Goto T, Tanaka H, Uemoto S. Human Atrial Natriuretic Peptide in Cold Storage of Donation after Circulatory Death Rat Livers: An Old but New Agent for Protecting Vascular Endothelia?- Transplantation. 2018 Nov 19. doi: 10.1097/TP.0000000000002552. [Epub ahead of print]
5. Tamaki I, Hata K, Okamura Y, Nigmet Y, Hirao H, Kubota T, Inamoto O, Kusakabe J, Goto T, Tajima T, Yoshikawa J, Tanaka H, Tsuruyama T, Tolba RH, Uemoto S .Hydrogen Flush After Cold Storage (HyFACS), as a new end-ischemic ex vivo treatment for liver grafts against ischemia/reperfusion injury. Liver Transpl. 2018 Nov;24(11):1589-1602.
6. ShiokawaM, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K, Yamazaki H, Morita T, Marui S, Sogabe Y, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Takahisa M, Uza N, Tsuruyama T, Mimori T, Seno H, Chiba T. Autoantibodies to the laminin 511 in patient with autoimmune pancreatitis. Sci Transl Med. 2018 Aug 8;10(453).
7. Nakajima A, Vogelzang A, Maruya M, Miyajima M, Murata M, Son A, Kuwahara T, Tsuruyama T, Yamada S, Matsuura M, Nakase H, Peterson DA, Fagarasan S, Suzuki K. IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria. J Exp Med. 2018 Aug 6;215(8):2019-2034.
8. Tsuruyama T. Analysis of Cell Signal Transduction based on Kullback-Leibler Divergence: Channel Capacity and Conservation of its Production Rate during Cascade．Entropy2018, June; 20(6), e438.
9. Yajima Y, Hiratsuka T, Kakimoto Y, Ogawa S, Shima K, Yamazaki Y, Yoshikawa K, Tamaki K, Tsuruyama T. Mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue. Sci Rep. 2018 May 10;8(1):7493.
10. Tsuruyama T. The Conservation of Average Entropy Production Rate in a Model of Signal Transduction: Information Thermodynamics Based on the Fluctuation Theorem. Entropy2018, Apr21, 20(4), 303.
11. Tsuruyama T. Information Thermodynamics of the Cell Signal Transduction as a Szilard Engine. Entropy 2018, March 26, 20, 224.
12. Hasegawa T, Ohashi H, Iwai S, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Kakizuka A, Yoshimura N. Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma. 2018 Feb27, 4(2), e00544.
13. Tsuruyama T. Information Thermodynamics Derives the Entropy Current of Cell Signal Transduction as a Model of a Binary Coding System. Entropy 2018 Feb 24, 20(2), 145.
14. Miyagawa-Hayashino A, Yoshifuji H, Kitagori K, Ito S, Oku T, Hirayama Y, Salah A, Nakajima T, Kiso K, Yamada N, Haga H, Tsuruyama T. Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes. Arthritis Res Ther. 2018 Jan 30;20(1):13.
15. Kanai　Y, Nishihara H, Miyagi Y, Tsuruyama T, Taguchi K, Katoh H, Takeuchi T, Gotoh M, Kuramoto J, Arai E, Ojima H, Shibuya A, Yoshida T, Akahane T, Kasajima R, Morita K, Inazawa J, Sasaki T, Fukayama M and Oda Y.　The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses (pages 63–90), Version of Record online: Pathology International. Pathol Int. 2018 Feb;68(2):63-90.（日本病理学会ゲノム病理組織取扱い規約委員会ゲノム研究用病理組織検体取扱規規程英語版、バイオバンク関連文書）
16. Tsuruyama T. Channel capacity of coding system on Tsallis entropy and q-Statistics. Entropy. 2017, 19, 682; e19120682.
17. Noda M, Ma Y, Yoshikawa Y, Imanaka T, Mori T, Furuta M, Tsuruyama T, Yoshikawa K. A single-molecule assessment of the protective effect of DMSO against DNA double-strand breaks induced by photo-and γ-ray-irradiation, and freezing. Sci. Rep 2017 Aug 17;7(1):8557.
18. Kiso K, Yoshifuji H, Oku T, Hikida M, Kitagori K, Hirayama Y, Nakajima T, Haga H, Tsuruyama T, Miyagawa-Hayashino A. Transgelin-2 is upregulated on activated B-cells and expressed in hyperplastic follicles in lupus erythematosus patients. PLoS One. 2017 Sep 14;12(9):e0184738.
19. Salah A, Yoshifuji H, Ito S, Kitagori K, Kiso K, Yamada N, Nakajima T, Haga H, Tsuruyama T, Miyagawa-Hayashino A. High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach. Patholog Res Int. 2017;2017:9312142.
20. Okumura S, Uemura T, Zhao X, Masano Y, Tsuruyama T, Fujimoto Y, Iida T, Yagi S, Bezinover D, Spiess B, Kaido T, Uemoto S. Liver graft preservation using perfluorocarbon improves the outcomes of simulated donation after cardiac death liver transplantation in rats. Liver transplantation. Liver Transpl. 2017 Sep;23(9):1171-1185.
21. Kaneshiro M, Yoshizawa A, Ueda Daisuke, Yagi S, Hata K, Okajima H, Kaido T, Tsuruyama T, Uemoto, S. Analysis of Human Leucocyte Antigen Class II Expression in Graft Liver Tissue; Donor Specific Antibodies and Graft Liver Fibrosis. Volume 101(5S-3) Supplement 3, May 2017, p S42.
22. Tsuruyama T. Kinetic Stability Analysis of Protein Assembly on the Center Manifold around the Critical Point. BMC Syst Biol. 2017 ;11(1):13.
23. Yoshioka Y, Mizutani T, Satoshi Mizuta S, Miyamoto A, Murata S, Ano T, Ichise H, Morita D, Hoshino Y, Tsuruyama T , and Sugita M.　Neutrophils and the S100A9 protein critically regulate granuloma formation. Blood advance 2016, 1(3);184-192.
24. Arakaki R, Yamasaki T, Kanno T, Shibasaki N, Sakamoto H, Utsunomiya N, Sumiyoshi T, Shibuya S, Tsuruyama T, Nakamura E, Ogawa O, Kamba T.　CCL2 as a potential therapeutic target for clear cell renal cell carcinoma. Cancer Med. 2016;5(10):2920-2933.
25. Tomoko Hasegawa, Yuki Muraoka, Hanako Ikeda, Tatsuaki Tsuruyama, Mineo Kondo, Hiroko Terasaki, Akira Kakizuka, and Nagahisa Yoshimura. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.　Sci. Rep. 6, 31184; doi: 10.1038/srep31184 (2016).
26. Tsuruyama T, Inoue H. Ethical Issues around the Use of Forensic Samples in Research in Japan. Int J Forensic Sci Pathol. 2016; 240-242.
27. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K.　Aquaporin-3 potentiates ovalbumin-induced murine asthma by mediating both chemokine production in alveolar macrophages and T cell trafficking. Sci Rep. 2016 May 11;6:25781. doi: 10.1038/srep25781.
28. Okumura S, Teratani T, Fujimoto Y, Zhao X, Tsuruyama T, Masano Y, Kasahara N, Iida T, Yagi S, Uemura T, Kaido T, Uemoto S.　Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats. Liver Transpl. Liver Transpl. 2016 Sep;22(9):1231-44.
29. Inoue H, Tsuruyama T. Regulations of regenerative medicine including clinical application of iPS cells in Japan. International Journal of Stem Cell Research and Transplantation. Int J Stem Cell Res Transplant 2016; 4 (4), 179-181.
30. Nakano N, Ikeda H, Tsuruyama T, Yoshimura N et al. Neuroprotective Effects of VCP Modulators in Mouse Models of Glaucoma. Heliyon. 2016;2(4):e00096.
31. Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. STAT5A modulates chemokine receptor CCR6 expression and enhances pre-B cell growth in a CCL20-dependent manner. J cellular biochemistry. J Cell Biochem. J Cell Biochem. 2016 Nov;117(11):2630-42.
32. Shimizu S, Fujita H, Sasaki Y, Tsuruyama T, Fukuda K, Iwai K. Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection. Mol Cell Biol. 2016 Mar 14. pii: MCB.01049-15.
33. Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T. Pathogenicity of IgG in patients with IgG4-related disease. Gut. 2016 Aug;65(8):1322-32.
34. Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene. 2016 Jun 23;35(25):3227-38.

 

Book Chapter and Reviews（peer-reviewed）

1. ゲノム研究用病理・診療用組織織検体取扱い規定、金井弥栄、石川俊平、西原広史、加藤洋人、宮城洋平、竹内朋代、田口健一、 佐々木毅 、鶴山竜昭 小田義直、2018 洋土社3.5.
2. Tsuruyama T. Information thermodynamics of cell signaling. Cell Signalling, IntechOpen, ISBN 978-953-51-6359-6. 11.5.
3. Tsuruyama T, Hiratsuka T, Novel Techniques in Histologic Research: Morphometry and Mass Spectrometry Imaging. Histology, IntechOpen, ISBN: 978-1-78984-971-4. 2018.8.27.0
4. Tsuruyama T. Information Thermodynamics of a Binary Code and Szilard Engine Model of Cell Signal Transduction. 2018, Entropy, Aug: 20(8), e617.
5. Tsuruyama T. Cytopathology of MDS/MPN and AML by H&E Staining. “Myeloid leukemia”, chapter 2. Intech, ISBN  978-1-78923-103-8.5.16.
6. Tsuruyama T. Non-Linear Kinetic Analysis of Protein Assembly Based on Center Manifold Theory. “Kinetic Theory”. ISBN 978-953-51-5718-2, 2017
7. Tsuruyama T, Hiratsuka T. Signal Pathway in Precursor B-Cell Lymphoblastic Leukemia/Lymphoma “Lymphocyte Updates – Cancer, Autoimmunity and Infection” edited by Gheorghita Isvoranu, ISBN 978-953-51-3344-5, Print ISBN 978-953-51-3343-8, InTech, July 7, 2017.
8. Tsuruyama T, Hiratsuka T, Yamada N. Hot spots of MLV integration in the hematopoietic tumor genome. Oncogene. 2017 Mar 2;36(9):1169-1175
9. Tsuruyama T.　Histopathology of Intestinal Transplant Rejections. SOJ immunology. 2016 SOJ Immunol 4(1): 1-7.
10. Tsuruyama T, Aini W. Telomeres in liver transplantation allografts. Telomere (ISBN 978-953-51-4609-4), 2016 Nov. 23. IntechOpen.
11. Gorecki J， Gorecka, JN， Nowakowski B, Ueno H, Tsuruyama T, Yoshikawa K. Sensing Parameters of a Time Dependent Inflow with an Enzymatic Reaction. January 2016 DOI: 10.1007/978-3-319-33921-4_4. Advances in Unconventional Computing, pp.85-104.

 

International Symposium

1. SMALL STEPS IN QUALITY MANAGEMENT LEAD TO BIG RESULTS: Piper Mullins and Tatsuaki Tsuruyama, International Society for biological and environmental repositories annual meeting 2017, 2018 May 24 (Dalas, Texas)

 

バイオバンク国際標準手続き書

1. ISO/TC276 Biotechnology — Biobanking — General requirements for biobanking (Élément introductif — Élément central — Élément complémentaire).
2. Jonas J. Astrin, Susan Baker, Katharine Barker, Thomas, J. Barr, Paul Bartels, Erica Benson, Penny Berents, Carol Butler, Mark Cada, Lori D. Campbell, Antonio Hugo Jose, Froes Marques Campos, David Carpentieri, Candace Carter, Marta Castelhano, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Gabriele Dröge, Helena Ellis, Oscar Estrada, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Denise Marie Guevarra, Keith Harding, Marianne J. Henderson, Chris J. Huddleston, Berthold Huppertz, John Jakubczak, Leo Joseph, Edward Kaercher, Joseph Kessler, Caroline Larson, Sarah Loud, Christopher Lyal, Jacqueline Mackenzie-Dodds, Hannah Maynor, Shannon McCall, KevinMcCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, Piper F. Mullins, James O’Sullivan, Francisco Javier Garcia Palomo, Ashokkumar A. Patel, Gitte Petersen, Karen Pitt, Olga Potapova, Rebecca Pugh, Pedro Rondot Radio, Rivka Ravid, Melissa Rawley- Payne, Marcy Revelez James Robb, Michael Roehrl, Oris Sanjur, William Schlief, Ole Seberg, Katherine Sexton, Weiping Shao, Ricardo Luis A. Silva, Amy Skubitz, Stella Somiari, Tatsuaki Tsuruyama, Frans van der Horst, Gavin Welch, Andy Zaayenga, Breda Marie Zimkus. Best practice: recommendation for repositories 4^th edition. International Society for biological and environmental repositories.

 

 

Reviews（peer-reviewed）

1. Takeshi Sakurai and Nao J. Gamo, Cognitive functions associated with developing prefrontal cortex during adolescence and developmental neuropsychiatric disorders. Neurobiology of Diseases, in press
2. Kevin Hui, Yuta Katayama, Keiichi Nakayama, Jun Nomura, and Takeshi Sakurai Characterizing vulnerable brain area and circuit in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches. Neuroscience and Behavior Reviews, in press
3. Anette Wu, Heike Kielstein, Takeshi Sakurai, Geoffroy Noel, Suvi Viranta-Kovanen, Chung-Liang Chien, and Paulette Bernd. Internationalization of medical education – building a program to prepare future leaders in healthcare. Medical Science Educator, in press
4. Hiroki Ishiguro, Kunio Miyake, Koichi Tabata, Chiaki Mochizuki, Takeshi Sakurai, and Emmanuel S. Onaivi Neuronal cell adhesion molecule regulating neural systems underlying addiction. Neuropsychopharmacology Reports, in press
5. Akiko Sumitomo, Kota Horike, Kazuko Hirai, Nancy Butcher, Erik Boot, Takeshi Sakurai, Frederick C. Nucifora Jr, Anne S. Bassett, Akira Sawa and Toshifumi Tomoda. A mouse model of 22q11.2 deletions: molecular and behavioral signatures of Parkinson’s disease and schizophrenia. Science Advances, 4, eaar6637, 2018
6. Akiko Sumitomo, Hiroshi Yukitake, Kazuko Hirai, Kouta Horike, Keisho Ueta, Youjin Chueng, Eiji Warabi, Toru Yanagawa, Shiho Kitaoka, Tomoyuki Furuyashiki, Shuh Naruiya, Tomoo Hirano, Minae Niwa, Etienne Sibille, Takatoshi Hikida, Takeshi Sakurai, Koko Ishizuka, Akira Sawa, and Toshifumi Tomoda.　Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.　Human Molecular Genetics, 27, 3165-3176, 2018
7. Takeshi Sakurai. Cognitive functions associated with developing prefrontal cortex during adolescence and developmental neuropsychiatric disorders. Neurobiology of Diseases, under revision
8. Takeshi Sakurai. Opinion: Training for circuitry based human neuroanatomy for the next generation in psychiatry and neuroscience. Molecular Neuropsychiatry, 3, 92-96, 2017
9. Toshifumi Tomoda, Takatoshi Hikida, and Takeshi Sakurai. Role of DISC1 in neuronal trafficking and its implication in neuropsychiatric manifestation and neurotherapeutics. Neurotherapeutics, 14, 623-629, 2017
10. Nao J. Gamo, Michelle R. Birknow, Danielle Sullivan, Mari A. Kondo, Yasue Horiuchi, Takeshi Sakurai, Barbara S. Slusher, and Akira Sawa. Valley of death: A proposal to build a “translational bridge” for the next generation. Neuroscience Research, in press
11. Takeshi Sakurai. The roles of cell adhesion molecules in brain wiring and neuropsychiatric disorders. Molecular and Cellular Neuroscience, in press

 

Book Chapter

1. Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa.  Neurodevelopmental mechanisms for psychotic disorders: Strategies to address mechanisms using animal and human cell models. Chapter in Charney and Nestler’s Neurobiology of Mental Illness, 5th edition, Dennis Charney, Eric J. Nestler, Pamela Sklar, Joseph Buxbaum, editors. Oxford University Press, 245-254, 2018

 

Translation

1. 村上 徹 (翻訳), 櫻井 武 (翻訳), 松崎利行 (翻訳)、臨床のための脳と神経の解剖学、メディカルサイエンスインターナショナル (April 23, 2019)

 

Japanese Articles

1. 櫻井武、友田利文.  脳神経回路と精神生物学：神経機能と心の根源を探る、２、神経回路と脳機能, Neural circuitry and brain functions, Clinical Calcium、28、844-850、2018
2. 櫻井武、谷口智彦、中村大和. 神経回路形成に働く遺伝子群、シナプス形成, Clinical Neuroscience、36、176-180、2018
3. 櫻井武.  連載、つながる産と学の手、オープンイノベーション時代にアカデミア人材ができること：第７回新たな連携②特定の疾患を標的としたNPOによる取り組み, Series, Academia Industry Collaboration: In the time of open innovation, what can academia do: 7, New wave No. 2, challenges of NPOs focusing on a particular disease, 実験医学、35、1524-1528、2017
4. 櫻井武. 連載、つながる産と学の手、オープンイノベーション時代にアカデミア人材ができること：第1回「学」の視点、2015年度で終了したTKプロジェクトをふまえての今後の産学連携へのアカデミアからの意見　実験医学、12月号

 

Presentations at Academic Conferences／Symposiums

1. T. Sakurai and Y. Nakamura. Analysis of mouse models for psychiatric disorders with social behavior alterations. Symposium “Animal model of autism, vulnerable brain area and circuit” in Annual meeting of International Behavioral Neuroscience Society, Hiroshima, Japan, June 2017
2. T. Sakurai and Y. Nakamura. Development and function of mouse prefrontal cortex. Cold Spring Harbor Meeting, “Wiring the brain”, Cold Spring Harbor, New York, Apr. 2017
3. T. Sakurai. Development and function of mouse prefrontal cortex. Symposium “Mechanisms regulating prefrontal cortex maturation: Relevance to psychiatric disorders” in Annual meeting of Japan Neuroscience Society, Yokohama, Japan, July 2016

 

 

Papers（peer-reviewed）　*corresponding author: Fujimoto Akihiro

1. Nguyen DT, Nguyen HH, Nguyen TD, Nguyen TTH, Nakano K, Maejima K, Sasaki-Oku A, Nguyen VB, Nguyen DB, Le BQ, Wong JH, Tsunoda T, Nakagawa H, Fujimoto A*, Nong VH (2018) Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability. Int J Environ Res Public Health 15
2. Ton ND, Nakagawa H, Ha NH, Duong NT, Nhung VP, Hien LTT, Hue HTT, Hoang NH, Wong JH, Nakano K, Maejima K, Sasaki-Oku A, Tsunoda T, Fujimoto A*, Van Hai N. Whole genome sequencing and mutation rate analysis of trios with paternal dioxin exposure. (2018) Hum Mutat. Jul 3. doi: 10.1002/humu.23585. [Epub ahead of print]
3. Shigemizu D, Miya F, Akiyama S, Okuda S, Boroevich KA, Fujimoto A, Nakagawa H, Ozaki K, Niida S, Kanemura Y, Okamoto N, Saitoh S, Kato M, Yamasaki M, Matsunaga T, Mutai H, Kosaki K, Tsunoda T (2018) Publisher Correction: IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis. Sci Rep 8: 10367
4. Taniguchi H, Fujimoto A, Kono H, Furuta M, Fujita M, Nakagawa H. Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer. (2018) Oncotarget. 25;9(40):26144-26156. doi: 10.18632/oncotarget.25456.
5. Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H. (2018) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. J Hepatol. 68:959-969. doi: 10.1016/j.jhep.2018.01.009.
6. Fujita M, Matsubara N, Matsuda I, Maejima K, Oosawa A, Yamano T, Fujimoto A, Furuta M, Nagano K, Oku-Sasaki A, Tanaka H, Shiraishi Y, Mateos RN, Sakai K, Miyano S, Tomita N, Hirota S, Ikeuchi H, and Nakagawa N. (2017) Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in RNF43 and Wnt signaling. Oncotarget (in press), doi: 10.18632/oncotarget.22867
7. Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Goto K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, Nakagawa H. (2017) Whole genome sequencing discriminate hepatocellular carcinoma with intrahepatic metastasis from multicentric tumors. J Hepatic. 66:363-373
8. Fujimoto A, Furuta M (equal contribution), Totoki Y (equal contribution), Tsunoda T (equal contribution), Kato M (equal contribution), Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata, Arihiro K, Boroevich KA, Abe T, Nagano K, Maejima K, Sasaki-Oku A, Oshawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Shashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusakan T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamane H, Chayama K, Miyano S, Aburatani H, Shibata T, and Nakagawa H. (2016) Whole genome mutational landscape and characterization of non-coding and structural mutations in liver cancer. Nat Genet 48: 500-509
9. Fujimoto A, Okada Y, Boroevich KA, Tsunoda T and Taniguchi H, and Nakagawa H. (2016) Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes. Sci Rep 6, Article number: 26483
10. Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Goto K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, Nakagawa H. (2016) Whole genome sequencing discriminate hepatocellular carcinoma with intrahepatic metastasis from multicentric tumors. J Hepatic. DOI: 10.1016/j.jhep.2016.09.021
11. Alexandrov LB, Ju YS, Haase K, Van Loo P, Martincorena I, Nik-Zainal S, Totoki Y, Fujimoto A, Nakagawa H, Shibata T, Campbell PJ, Vineis P, Phillips DH, Stratton MR. (2016) Mutational signatures associated with tobacco smoking in human cancer. Science 354:618-622.

 

Japanese Articles

1. 藤本明洋　肝癌の全ゲノムシークエンス解析. 　医学のあゆみ August 4, 2018
2. 藤本明洋　ゲノムシークエンスデータの情報解析. 　生物物理 58(3),001-003 (2018）
3. 藤本明洋 進化遺伝学とがんゲノム解析. 実験医学 増刊 2018 年

 

Presentations at Academic Conferences／Symposiums

1. 藤本明洋、Identification of structural variations and analysis of their functional roles 、日本分子生物学会　国際シンポジウム、  November 30, 2018
2. 藤本明洋、ヒトのゲノム配列の解析と今後の課題；ゲノム解析の基礎、がんゲノム研究、リキッドバイオプシーの個別化医療への応用、薬物動態談話会、November 16, 2018
3. 藤本明洋、Whole-genome sequencing and mutational landscape in cancer genomes、筑波大学セミナー、  November 1, 2018
4. A Fujimoto、Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types 、American Society of Human Genetics、October 19, 2018
5. 藤本明洋、２１癌種におけるマイクロサテライトの変異解析、日本人類遺伝学会、October 12, 2018
6. Hao、Identification and characterization of intermediate-sized deletions within a Japanese population、日本人類遺伝学会、 October 12, 2018
7. 藤本明洋、全ゲノムシークエンスによるゲノム解析の現状と今後の課題、生命情報研究会（京都大学）、  July 3, 2018
8. 藤本明洋、全ゲノムシークエンスによるゲノム解析の現状と今後の課題、千葉大学リーディング大学院セミナー、  June 30, 2018
9. 藤本明洋、全ゲノムシークエンスによるゲノム解析の現状と今後の課題、糖尿病学会、  May 25, 2018
10. 筑波大学 セミナー（2018）Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
11. 日本人類遺伝学会 ワークショップ（2017）情報解析と⼈類遺伝学
12. International Symposium on Major Southeast Asia Infectious Diseases in Taiwan (2017) Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
13. INTERNATIONALCONFERENCE ON GENOME SCIENCE: FROM BASIC RESEARCH TO APPLICATIONS in Vietnam (2017) Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
14. International Workshop for Systems Genetics (2017) Whole genome sequence and comprehensive variant analysis of human and cancer genome
15. 第30回肝臓フォーラム (2017) Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
16. Fujimoto, Akihiro et al. 全ゲノムシークエンスによる肝癌の変異の包括的解析,　THE GENETICS SOCIETY OF JAPAN, Japan, 2016

 

Award Lectures

1. 日本人類遺伝学会 受賞講演（2017）次世代シークエンスデータの解析手法の開発と、日本人及び肝臓癌の全ゲノム解析
2. 臨床腫瘍学会 (2017) Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
3. 理研 AIP センター セミナー (2017) ヒトのゲノム配列の解析と今後の課題

 

Awards

1. Taisho Toyama Award, 2017
2. The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture,Sports, Science and Technology of Japan, 2017
3. The 8th Research Encouragement Award from RIKEN, 2016
4. The 35th Encouragement Award from the Japanese Cancer Association, 2016
5. Encouragement Award from the Japan Society of Human Genetics for academic year 2016

 

AMED (Japan Agency for Medical Research and Development) Grant Programs

1. Co-investigator, Program for an Integrated Database of Clinical and Genomic Information, ”B型肝炎に関する統合的臨床ゲノムデータベースの構築を目指す研究”
2. Principal Investigator, Platform Program for Promotion of Genome Medicine（先端ゲノム研究開発）, ”先進的シークエンス情報解析技術基盤の開発”
3. Principal Investigator, Practical Research for Innovative Cancer Control, “Liquid Biopsyのゲノムシークエンス解析による癌の変異プロファイル”

 

 

Papers（peer-reviewed）

1. Region of Interest analysis using mass spectrometry imaging of mitochondrial and          sarcomeric proteins in acute cardiac infarction tissue. Yajima Y, Hiratsuka T, Kakimoto Y, Ogawa S, Shima K, Yamazaki Y, Yoshikawa K, Tamaki K, Tsuruyama T. Sci Rep. 2018 May 10;8(1):7493. doi: 10.1038/s41598-018-25817-7.
2. Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer. Hiratsuka T, Sano T, Kato H, Komatsu N, Imajo M, Kamioka Y, Sumiyama K, Banno F, Miyata T, Matsuda M. J Thromb Haemost. 2017 Apr 28.
3. Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. SanoT, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou LS, Ogawa O, Matsuda M. Physiol Rep. 2016 Nov;4(21). pii: e13033. Epub 2016 Nov 15.
4. Hotspots of MLV integration in the hematopoietic tumor genome. Tsuruyama T, Hiratsuka T, Yamada N. Oncogene. 2017 Mar 2;36(9):1169-1175. doi: 10.1038/onc.2016.285. Epub 2016 Nov 7.
5. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. J Cell Biochem. 2016 Nov;117(11):2630-42. doi: 10.1002/jcb.25558. Epub 2016 Apr 14.
6. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T. Oncogene. 2016 Jun 23;35(25):3227-38. doi: 10.1038/onc.2015.385. Epub 2015 Nov 2.

 

Presentations at Academic Conferences／Symposiums

1. 平塚　拓也、佐野　剛視、松田　道行。In vivo imaging reveals the regulation of thrombus formation by ERK and PKA activity. 第80回日本血液学会学術集会、大阪国際会議場 (October 12, 2018)
2. Takuya Hiratsuka, Takeshi Sano, Michiyuki Matsuda. In vivo imaging reveals the regulation of thrombus formation by ERK and PKA activity. 64TH ANNUAL ISTH SSC MEETING, Convention Center Dublin, Dublin, Ireland. (July 18, 2018)、Oral presentation
3. Hiratsuka, Takuya et al.
   In vivo imaging reveals the regulation of thrombus formation by ERK and PKA activity.
   The 104th Japanese Society of Pathology Conference for Investigative Pathology, July 28, 2017
4. Hiratsuka, Takuya et al.
   In vivo imaging reveals the regulation of thrombus formation by ERK and PKA activity.
   The 106th Annual Meeting of the Japanese Society of Pathology, April 27, 2017
5. Hiratsuka, Takuya et al.
   In vivo imaging reveals the regulation of thrombus formation by ERK and PKA activity.
   The 105th Annual Meeting of the Japanese Society of Pathology, May 14, 2016

 

Others

1. Site visit at University of Luxembourg Biobank (IBBL), June 12, 2017 – July 3, 2017

 

Papers

1. Tetsunori Sakamoto, Masahiko Ajiro# (#, co-corresponding), Akira Watanabe, Shingo Matsushima, Keiji Ueda, Masatoshi Hagiwara#. Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy. BMC Cancer. 2023 Jan 20;23(1):71.
2. Shingo Matsushima, Masahiko Ajiro# (#, co-corresponding), Kei Iida, Kenji Chamoto, Tasuku Honjo, Masatoshi Hagiwara#. Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer. Sci. Transl. Med., 2022, 14(673):eabn6056.
3. Masahiko Ajiro「第二章・遺伝子発現の基本性質から遺伝性疾患・治療方法まで」『書籍名：mRNAの制御機構の解明と治療薬・ワクチンへの活用（技術情報協会）February, 2023』
4. Takahiro Nishino, Akihide Yoshimi, Masahiko Ajiro「第五章・遺伝子発現機構から考える遺伝子コントロール：スプライシング異常による発がん機構の解明」『書籍名：mRNAの制御機構の解明と治療薬・ワクチンへの活用（技術情報協会）February, 2023』
5. Masahiko Ajiro, Masatoshi Hagiwara「RNAスプライシング制御を標的とした創薬」『生化学94巻6号特集：mRNAスプライシング制御の最前線と創薬への応用』（日本生化学会）
6. Masahiko Ajiro, Masatoshi Hagiwara「スプライシング疾患の低分子創薬に向けて―家族性自律神経失調症に対する候補化合物RECTAS (Drug development targeting splicing diseases―Therapeutic potential of RECTAS for familial dysautonomia)」『医学のあゆみ』（医歯薬出版）(2022) 280(11): 1166-1167.
7. Kei Iida*, Masahiko Ajiro* (*, equal contribution) Yukiko Muramoto, Toru Takenaga, Masatsugu Denawa, Ryo Kurosawa, Takeshi Noda, and Masatoshi Hagiwara. Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection. (Preprint article, 2021, DOI: 10.1101/2021.08.23.457314)
8. Masahiko Ajiro, Tomonari Awaya, Young Jin Kim, Kei Iida, Masatsugu Denawa, Nobuo Tanaka, Ryo Kurosawa, Shingo Matsushima, Saiko Shibata, Tetsunori Sakamoto, Rolenz Studer, Adrian R. Krainer, Masatoshi Hagiwara. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nat. Commun., 2021, 12(1):4507.
9. Simon Uzor, Sean R. Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A. Alqasem, Claire M. Perks, Ian D. Wilson, Sebastian Oltean, Michael R. Ladomery. CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Sci. Rep., 2021, 11(1):7963.
10. Masahiko Ajiro, Masatoshi Hagiwara「スプライシング疾患の低分子創薬に向けて―家族性自律神経失調症に対する候補化合物RECTAS (Drug development targeting splicing diseases―Therapeutic potential of RECTAS for familial dysautonomia)」『医学のあゆみ』（医歯薬出版）(2022) 280(11): 1166-1167.
11. Saiko Shibata, Masahiko Ajiro# (#, co-corresponding), Masatoshi Hagiwara#. Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion. Cell Chem. Biol., 2020, 27(12):1472-1482.
12. Jia Rong*, Masahiko Ajiro* (*, equal contribution), Lulu Yu, Phillip McCoy  Jr, and Zhi-Ming Zheng. Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation. RNA, 2019 May, 25(5):630-644.
13. Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Journal of Clinical Investigation, 2019, 129(2):583-597.
14. Masahiko Ajiro, Hiroyuki Sakai, Hiroshi Onogi, Makoto Yamamoto, Eriko Sumi, Teruo Sawada, Takashi Nomura, Kenji Kabashima, Takamitsu Hosoya, and Masatoshi Hagiwara. CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 and has therapeutic effect on HPV-induced neoplasia. Cancer Res., 2018, 24(18):4518-4528.
15. Wang X, Liu H, Ge H, Ajiro M, Sharma NR, Meyers C, Morozov P, Tuschl T, Klar A, Court D, Zheng ZM. Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter. MBio. 2017 May 30;8(3). pii: e00713-17.
16. Ngoc NB, Okuno Y, Ajiro. M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M. Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. J Med Virol. 2017 Jul;89(7):1224-1234.
17. Ajiro M, Tang S, Doorbar J and Zheng, ZM.  Serine/arginine-rich splicing factor 3 and heterogeneous nuclear ribonucleoprotein A1 regulate alternative RNA splicing and gene expression of human papillomavirus type 18 through two functionally distinguishable cis-elements.  J Virol. 2016 Sep 29;90(20):9138-52.
18. Ajiro M, Jia R, Yang Y, Zhu J, Zheng ZM. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res. 2016 Feb 29;44(4):1854-70.
19. Wang P, Zhou Z, Hu A, de Albuquerque CP, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan CL, Zheng ZM, Newton AC, Sun P, Zhou H, and Fu XD. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Molecular Cell, 2014, 54: 1-14.

Review

1. 網代 将彦、萩原正敏「RNAスプライシング異常を標的とした創薬展開/Drug Development by Targeting Aberrant RNA Splicing」『Medical Science Digest』誌（ニュー・サイエンス社）(2020) 46(9):550-554.
2. 網代将彦「スプライシング応答の可視化―スプライシング変異から挑むプレシジョンメディシン」 『Precision Medicine』誌（北隆館） 2019年6月号

Invited Lectures

1. Masahiko Ajiro, Tomonari Awaya, Masatoshi Hagiwara. スプライシング標的化合物による筋疾患治療への挑戦. 第７回 日本筋学会学術集会 シンポジウム, 京都大学百周年時計台記念館・ハイブリッド開催（12/11/2021 – 12/12/2021) (12/11/2021)
2. Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer Adrian, Masatoshi Hagiwara. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. 第４４回 日本分子生物学会年会ワークショップ『Getting to the crux of gene expression mechanisms through chemical biology』, パシフィコ横浜／Hybrid meeting（12/1/2021 – 12/3/2021) (12/1/2021）
3. Masahiko Ajiro. Pan-Antiviral Drug FIT039. 2017 BIO SPARK Showcase, San Francisco, USA (10/16/2017).
4. Masahiko Ajiro. Development of small molecule therapeutic compound targeting HPV. Cell Biology, Developmental Biology, and Systems Biology Course Retreat (9/2/2017), Kyoto University Rakuyu Kaikan

Presentations at Academic Conferences／Symposiums

（Oral Presentation）

1. Masahiko Ajiro 「スプライス・ネオ抗原の探索」国立がん研究センター・セミナー（November 25, 2022）
2. Ryo Kurosawa, Masahiko Ajiro, Kei Iida, Tomonari Awaya, Mamiko Yamada, Kenjiro Kosaki, Masatoshi Hagiwara. In silico strategy for the identification of deep-intronic variants causing aberrant splicing. 日本人類遺伝学会第67回大会 (Dec. 14-17, 2022), パシフィコ横浜
3. Koichi Kato, Hideyuki Jinzai, Takeru Makiyama, Yuichi Sawayama, Ryotaro Kida, Ryo Kurosawa, Masahiko Ajiro, Seiko Ohno, Yoshihisa Nakagawa, Minoru Horie. Correction of SCN5A splicing error of Brugada syndrome patient by antisense oligo nucleotides. 15th APHRS Scientific Session / 第15回アジア太平洋不整脈学会 (Nov. 18-20, 2022), Suntec Singapore Convention & Exhibition Centre, Singapore 
4. Masahiko Ajiro, Shingo Matsushima, Kei Iida, Kenji Chamoto, Tasuku Honjo, and Masatoshi Hagiwara. Inducible splice-neoantigens suppress tumor growth through anti-tumor immunity. 第23回日本RNA学会年会（July 20, 2022）, みやこメッセ, Kyoto
5. Atsushi Taguchi, Masahiko Ajiro, Yo Kishimoto, Koichi Omori, Masatoshi Hagiwara. Investigation of splicing modulator-induced splice-neoantigens for head and neck cancer. 第23回日本RNA学会年会（July 21, 2022）, みやこメッセ, Kyoto
6. Junzo Hamanishi, Eriko Sumi, Taito Miyamoto, Koji Yamanoi, Ryuji Uozumi, Harue Tada, Yoko Amino, Yu Hidaka, Masayo Ukita, Ken Yamaguchi, Ryuta Asada, Masahiko Ajiro, Teruo Sawada, Masatoshi Hagiwara, Masaki Mandai. Safety of the cyclin dependent kinase 9 (CDK9) inhibitor FIT039 for cervical intraepithelial neoplasia (CIN) 1 or 2 in a phase I/II trial. ASCO2022, Chicago／US（June 3-7, 2022）( Clin. Oncol., 2022, 40(16) suppl. 2022 ASCO Annual Meeting, DOI: 10.1200/JCO.2022.40.16_suppl.3022)
7. Shingo Matsushima, Masahiko Ajiro, Kenji Chamoto, Tasuku Honjo, Masatoshi Hagiwara. Boosted tumor immunogenicity by splicing modulation potentiates the response to immune checkpoint therapy. 第４４回 日本分子生物学会年会, パシフィコ横浜／Hybrid meeting (December 1-3, 2021) (December 1, 2021)
8. Kei Iida, Masahiko Ajiro, Yukiko Muramoto, Toru Takenaga, Masatsugu Denawa, Ryo Kurosawa, Takeshi Noda, Masatoshi Hagiwara. Precision Medicine to Provide Resistance to SARS-CoV-2 Infection by Switching OAS1 Splicing Isoforms. 第４４回 日本分子生物学会年会, パシフィコ横浜／Hybrid meeting (December 1-3, 2021) (December 1, 2021)
9. Ryo Kurosawa, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara. Comprehensive analysis of whole-genome sequence for deep-intronic splicing-associated variant. 第４４回 日本分子生物学会年会, パシフィコ横浜／Hybrid meeting（December 1-3, 2021) (December 2, 2021）
10. Kei Iida, Masahiko Ajiro, Yukiko Muramoto, Toru Takenaga, Masatsugu Denawa, Ryo Kurosawa, Takeshi Noda, and Masatoshi Hagiwara. Precision Medicine to Provide Resistance to SARS-CoV-2 Infection by Switching OAS1 Splicing Isoforms. Cold Spring Harbor Laboratory Eukaryotic mRNA Processing Meeting. Online (August 27, 2021)
11. Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer R. Adrian, and Masatoshi Hagiwara. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. 第22回日本RNA学会年会. Online (July 9, 2021）
12. Shingo Matsushima, Masahiko Ajiro, Kei Iida, Kenji Chamoto, and Masatoshi Hagiwara. New strategy for enhancing tumor immunity by splicing modulator-mediated splice-neoantigens. 京都大学 発生細胞生物学システム生物学リトリート. Online (January 23, 2021)
13. Masahiko Ajiro, Masatoshi Hagiwara. Amending splicing defects by small molecule compounds/低分子化合物による病原性スプライシングの制御. 第43回日本分子生物学会年会・MBSJ 2020 Workshop『Pathogenic defect and chemical manipulation of RNA processing/化合物によるRNAプロセシング制御を介した疾患の理解と制圧』 Online (December 2-4, 2020)
14. Ryo Kurosawa, Masahiko Ajiro, Masatoshi Hagiwara. 偽エクソン型スプライス変異の探索と化合物応答性評価/Investigation of pathogenic pseudo exons and their amendment by small molecules. 第43回日本分子生物学会年会　Online (December 2-4, 2020)
15. Masahiko Ajiro, 粟屋智就, 田中信生, Masatoshi Hagiwara. 心ファブリー病に対するスプライシング制御化合物に関する研究開発  国立研究開発法人日本医療研究開発機構 2事業合同成果報告会「疾患克服への挑戦2019」大手町プレイスカンファレンスセンター, Tokyo (February 7, 2020)
16. Masahiko Ajiro, 本田吉孝, 八角高裕, Masatoshi Hagiwara. Application of Splice-Targeting Small Molecule Compounds for Pathogenic Pseudo Exons Caused by Deep-Intronic Mutations. 病原性深部イントロン変異に起因する偽エクソンを標的としたスプライシング制御化合物の検討 京都大学メディカルイノベーション卓越大学院プログラム・医薬系研究交流サロン, Kyoto (January 31, 2020)
17. Masahiko Ajiro, 本田吉孝, 八角高祐, Masatoshi Hagiwara. 深部イントロン変異に起因する偽エクソンを標的としたCLK-SRSF経路阻害効果. 第42回 日本分子生物学会年会, 国際会議場, Fukuoka (December 6, 2019)
18. Momoka Ryu, Masahiko Ajiro, Masatoshi Hagiwara. MTRR遺伝子偽エクソン型変異に対するCLK阻害化合物の検討. 第42回 日本分子生物学会年会, 国際会議場, Fukuoka (December 4, 2019)
19. Masahiko Ajiro and Masatoshi Hagiwara. Oncogenic role of splicing factor SRSF3 through ILF3 and targeting SR protein function by CLK inhibitor. 第78回日本癌学会学術総会
20. Masahiko Ajiro, Yoshitaka Honda, Jean Laurent Casanova, Takahiro Yasumi, and Masatoshi Hagiwara. Therapeutic effect of CLK inhibition for EDA-ID caused by the IVS4+866 C>T deep-intronic mutation of NEMO gene. Cold Spring Harbor Laboratory eukaryotic mRNA processing meeting, NY, USA (August 20-24, 2019).
21. Masahiko Ajiro. CLK-SRSF経路の阻害による偽エクソン型スプライシング疾患の治療効果. 第21回 日本RNA学会年会, 東京大学伊藤国際学術センター. (July 19, 2019)
22. Tetsunori Sakamoto, Masahiko Ajiro, Keiji Ueda, and Masatoshi Hagiwara. Assessment of antiviral effect of FIT-039 against Kaposi’s sarcoma-associated herpesvirus. 世界をリードする次世代MD研究者・養成プロジェクト2019年度全国リトリート, 名古屋国際会議場, Aichi (April 29, 2019)
23. Masahiko Ajiro, Tomonari Awaya, and Masatoshi Hagiwara. Splicing therapy for cardiac Fabry Disease. Cold Spring Harobor Asia, RNA biology, Suzhou, China (Oct. 29-Nov. 2, 2018).
24. Masahiko Ajiro, Hiroyuki Sakai, Makoto Yamamoto, Hiroshi Pnogi, Takamitsu Hosoya, and Masatoshi Hagiwara. CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 with a therapeutic effect for HPV-induced neoplasia. 7^th Annual Conference of ICBS, Vancouver, Canada (September 24-27, 2018).
25. Masahiko Ajiro, Hiroyuki Sakai, Hiroshi Onogi, Takashi Nomura, Kenji Kabashima, and Masatoshi Hagiwara. CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 and has therapeutic effect on HPV-induced neoplasia. WCP2018/18^th World Congress of Basic and Clinical Pharmacology, Kyoto International Conference Center, Kyoto, Japan (June 1-6, 2018).
26. Masahiko Ajiro, Hiroyuki Sakai, Makoto Yamamoto, Hiroshi Onogi, Takamitsu Hosoya, and Masatoshi Hagiwara. Clinical Development of Anti-HPV Therapeutics by Small Molecule Compound. The 65th Annual Meeting of the Japanese Society for Virology, Osaka International Convention Center (October 26, 2017)
27. Masahiko Ajiro “Clinical Development of Anti-HPV small molecule compound/ Development of small molecule therapeutics for genetic diseases” Department of Drug Discovery Medicine Lab Meeting, Kyoto University Medical Innovation Center (October 10, 2017)
28. Masahiko Ajiro, Masatoshi Hagiwara “Clinical Development of Anti-HPV Therapeutics by Small Molecule Compound” The 76th Annual Meeting of the Japanese Cancer Association, PACIFICO Yokohama (September 28, 2017)
29. Masahiko Ajiro et al. “Development of anti-HPV compound to prevent malignant progression of cervical intraepithelial neoplasia” The 12th Annual Meeting of Japanese Society for Chemical Biology, Hokkaido University Clark Memorial Student Center  (June 9, 2017)
30. Xiaohong Wang, Haibin Liu, Hui Ge, Masahiko Ajiro, Nishi Sharma, Craig Meyers, Amar Klar, Donald Court, Louise Chow, and Zhi-Ming Zheng. Viral DNA replication regulates HPV18 transcription and gene expression. DNA Tumor Virus Meeting (July 17-22, 2017), Birmingham, UK.

（Poster Presentation）

1. 黒澤凌, Masahiko Ajiro, 飯田慶, Tomonari Awaya, Masatoshi Hagiwara. 病原性深部イントロン変異の検出に向けたスクリーニング手法の検討. 第７回 日本筋学会学術集会, 京都大学百周年時計台記念館. Hybrid meeting (December 11-12, 2021) (December 11, 2021) 
2. 牧ケ谷佳佑, 牧山武, Masahiko Ajiro, Masatoshi Hagiwara. 先天性QT延長症候群I型に対するスプライシング制御化合物の検討. 第７回 日本筋学会学術集会, 京都大学百周年時計台記念館. Hybrid meeting (December 11-12, 2021) (December 11, 2021)
3. Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer R. Adrian, and Masatoshi Hagiwara. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Cold Spring Harbor Laboratory Eukaryotic mRNA Processing Meeting. Online (August 25-27, 2021)
4. 黒澤凌, Masahiko Ajiro, Masatoshi Hagiwara. Genome-wide Screening for Pseudo-exonic Variants and their Modulation by CLK Inhibitors. 京都大学メディカルイノベーション卓越大学院プログラム・医薬系研究交流サロン. Online (April 19-21, 2021) (April 21, 2021)
5. Masahiko Ajiro, Tomonari Awaya, 牧山武, 田中信生, Masatoshi Hagiwara.  心ファブリー病に対するスプライシング制御化合物に関する研究開発 AMED 6事業合同成果報告会 “疾患克服への挑戦2018”, 東京国際フォーラム, Tokyo  (February 7-8, 2019)
6. Masahiko Ajiro, Young-Jin Kim, Tomonari Awaya, Lorenz Studer, Adrian R. Krainer, and Masatoshi Hagiwara. Therapeutic effect of RECTAS for familial dysautonomia by activating SRSF6 on IKBKAP splicing enhancer. 武田科学振興財団生命科学シンポジウム RNA neobiology, 武田薬品研修所, Osaka (February 1-2, 2019)
7. Masahiko Ajiro, Young-Jin Kim, Tomonari Awaya, Lorenz Studer, Adrian R. Krainer, and Masatoshi Hagiwara. Therapeutic effect of RECTAS for familial dysautonomia by activating SRSF6 on IKBKAP splicing enhancer. SRSF6活性化によるIKBKAPスプライシング制御を介した家族性自律神経失調症に対するRECTASの治療効果検討 第41回日本分子生物学会年会, パシフィコ横浜, Kanagawa (November 28-30, 2018).
8. 飯田慶, 豊島裕美, Masahiko Ajiro, 出縄政嗣, Masatoshi Hagiwara. SRタンパク質結合情報の統合によるスプライシング操作化合物の標的エキソン探索アルゴリズムの改良 第41回日本分子生物学会年会, パシフィコ横浜, Kanagawa (November 28-30, 2018).
9. 豊島裕美, 飯田慶, Masahiko Ajiro, 豊本雅靖, 出縄政嗣, Masatoshi Hagiwara. 家族性自律神経失調症患者由来の細胞において低分子化合物RECTASに応答するスプライシング変化のトランスクリプトーム解析 第41回日本分子生物学会年会, パシフィコ横浜, Kanagawa (November 28-30, 2018).
10. Masahiko Ajiro, Young-Jin Kim, Tomonari Awaya, Lorenz Studer, Adrian R. Krainer, and Masatoshi Hagiwara. Therapeutic effect of RECTAS for familial dysautonomia by activating SRSF6 on IKBKAP splicing enhancer. Cold Spring Harobor Asia, RNA biology, Suzhou, China (Oct. 29-Nov. 2, 2018).
11. Tetsunori Sakamoto, Masahiko Ajiro, Keiji Ueda, and Masatoshi Hagiwara. Assessment of antiviral effect of FIT-039 against Kaposi’s sarcoma-associated herpesvirus. 第66回日本ウイルス学会学術集会, Kyoto (October 28-30, 2018)
12. Saiko Shibata, Masahiko Ajiro, and Masatoshi Hagiwara. Development of small molecule compounds for treating cystic fibrosis patients carrying the splicing mutation. 7^th Annual Conference of ICBS, Vancouver, Canada (September 24-27, 2018).
13. Goh Zheng Cong, Masahiko Ajiro, and Masatoshi Hagiwara. Drug screening for cobalamine E-type of Homocystinuria (cblE-HU), caused by splicing mutation. Amgen Scholar program meeting, Kyoto University (August 2, 2018).
14. Saiko Shibata, Masahiko Ajiro, and Masatoshi Hagiwara. Identification of therapeutic small molecule compound for cystic fibrosis by targeting pseudo exon-inclusion. WCP2018/18^th World Congress of Basic and Clinical Pharmacology, Kyoto International Conference Center, Kyoto, Japan (June, 1-6, 2018).
15. Masahiko Ajiro, Young-Jin Kim, Tomonari Awaya, Lorenz Studer, Adrian R. Krainer, and Masatoshi Hagiwara. Therapeutic Effect of RECTAS for Familial Dysautonomia by Activating SRSF6 on IKBKAP Intronic Splicing Enhancer. 23rd annual meeting of RNA society, University of California, Berkeley, CA (May 29-June 3, 2018)
16. Tetsunori Sakamoto, Masahiko Ajiro, and Masatoshi Hagiwara. Antiviral effect of CDK9 inhibitor against Kaposi’s sarcoma associated herpesvirus. MD researcher training program 2017 Retreat (ConBio2017 Forum), Ariston Hotel Kobe (December 9, 2017)

AMED (Japan Agency for Medical Research and Development) and other Grant Programs

1. Masahiko Ajiro. “スプライスネオ抗原の誘導による癌免疫応答の解析” FY 2022, 京都大学研究費獲得支援事業【いしずえ】　
   
2. “RNA結合タンパク質の病的相分離の統合的理解”  JSPS 基盤研究（S）（Principal Investigator：Masatoshi Hagiwara） Research Collaborator（FY 2021～2025）
3. Masahiko Ajiro. “遺伝病におけるCLKを介した偽エクソン制御機構の解析”  JSPS 基盤研究（C）（FY 2019～2020）
4. “深部イントロン変異に対するデータ駆動型ハイスループットアッセイ系の開発と診断・創薬への応用”  AMEDゲノム創薬基盤推進研究事業（Principal Investigator：Masatoshi Hagiwara）Co-investigator（2020-5-01 – 2023-3-31）
5. “偽エクソン化抑制化合物による心ファブリー病の根治・予防を可能とする治療薬の創製” AMED 橋渡し研究戦略的推進プログラム（シーズB課題）
   （Principal Investigator：Masatoshi Hagiwara）
   Co-investigator（FY 2018～2020）
6. “Development of novel therapeutics of cardiac Fabry disease with the splicing modifier compound.”AMED難治性疾患実用化研究事業・希少難治性疾患に対する画期的な医薬品の実用化に関する研究（治験準備　ステップ1）
   （Principal Investigator：Masatoshi Hagiwara）
   Co-investigator（FY 2018～2020）
7. “先天性QT延長症候群スプライシング変異を標的とした創薬開発”
   AMED難治性疾患実用化研究事業・希少難治性疾患・未診断疾患領域における革新的開発候補物の非臨床POC確立を目指す研究
   （Principal Investigator：Takeru Makiyama）
   Co-investigator（FY 2017～2019）
8. “Elucidation of regulatory mechanisms for latent infection in progenitor cells and molecular mechanisms for virus reactivation along with cell differentiation.”
   AMED感染症領域感染症研究革新イニシアティブ事業
   （Principal Investigator：Ayumi Taguchi）
   Research Collaborator（FY 2017～2019）
9. “スプライシング操作化合物を対象としたファーマコゲノミクス解析に基づく遺伝性難病治療薬の開発研究” AMED ゲノム医療実用化推進研究事業
   （Principal Investigator：Masatoshi Hagiwara）
   Research Collaborator（FY 2016～2018）
10. “CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創成”  JSPS 基盤研究（S）（Principal Investigator：Masatoshi Hagiwara）
    Research Collaborator（FY 2015～2019）
11. “肝炎ウイルスの複製増殖および病原性発現機構と薬剤感受性の解析” AMED 肝炎等克服緊急対策研究事業
    （Principal Investigator：Takaji Wakita）
    Research Collaborator（FY 2014～2018）

Patent

1. ウイルスを原因とする腫瘍を抑制する医薬組成物
   Applicant: Kyoto University,   Inventor: Masatoshi Hagiwara, Masahiko Ajiro, 阪本哲紀.
2. アルツハイマー病のための医薬組成物
   Applicant: Kyoto University,   Inventor: Masatoshi Hagiwara, Masahiko Ajiro.
3. ヒトパピローマウイルスの排除方法
   Applicant: Kyoto University,   Inventor: Masatoshi Hagiwara, Masahiko Ajiro, 小野木博.
4. スプライシング異常に起因する遺伝性疾病のための医薬組成物及び治療方法（出願）Applicant: Kyoto University,   Inventor: Masatoshi Hagiwara, Masahiko Ajiro.